动物营养学报2019，Vol.31Issue(10)：4434-4441,8.DOI:10.3969／j.issn.1006⁃267x.2019.10.004
反刍动物肝脏糖异生及营养调控
Mechanisms of Hepatic Gluconeogenesis and Nutritional Regulation in Ruminants
摘要
Abstract
Glucose is the main energy substrate, which plays an important role in mammalian metabolism. Ru?minants have a large reliance on gluconeogenesis in terms of meeting the glucose requirement, and liver com?prises mainly of the total gluconeogenesis capacity. Important pathways／signal factors including phosphatidyli?nositol 3 kinase／protein kinase B?forkhead box protein O1( PI3K／Akt?FoxO1) , AMP?activated protein kinase ( AMPK) , and mammalian target of rapamycin ( mTOR) are closely related to the hepatic gluconeogenesis, and nutrition substrates, enzyme activity, and hormone play an important role in regulation of hepatic glucone?ogenesis in ruminants. Therefore, the mechanism of hepatic gluconeogenesis as well as the influence of nutri?tional regulations were summarized in this article, in order to provide the basic knowledge and reference for im?provement of ruminant health, growth and production performance.[ Chinese Journal of Animal Nutrition, 2019, 31(10) :4434?4441]关键词
糖异生/基因表达/酶活/营养调控/反刍动物/肝脏Key words
gluconeogenesis/gene expression/enzyme activity/nutritional regulation/ruminant/liver分类
农业科技引用本文复制引用
朱雯,任春环,张彦,张子军..反刍动物肝脏糖异生及营养调控[J].动物营养学报,2019,31(10):4434-4441,8.基金项目
国家重点研发计划项目(2018YFD0502001) （2018YFD0502001）
安徽农业大学青年基金重点项目(2018zd18) （2018zd18）
安徽农业大学稳定人才项目( yj2018⁃53) （ yj2018⁃53）
国家肉羊产业技术体系( CARS⁃38) （ CARS⁃38）
