动物营养学报2019，Vol.31Issue(10)：4494-4501,8.DOI:10.3969／j.issn.1006⁃267x.2019.10.012
氨基酸调控细胞自噬的分子机制
Molecular Mechanisms of Amino Acids Regulating Cell Autophagy
摘要
Abstract
Autophagy is a " self?feeding " phenomenon commonly found in eukaryotic cells, which mainly manifests that damaged proteins or organelles in cells are encapsulated by autophages and transported to lyso?somes for degradation. There are many factors leading to autophagy, among which the mechanism of nutrient deficiency inducing autophagy has always been the focus of research. Early studies have shown that amino acid deficiency?induced autophagy is mainly mediated by mammalian rapamycin target protein complex 1 ( mTORC1) signaling pathway. In addition, some studies have found that some non?mTORC1 signaling path?ways play an important role in the regulation of autophagy, and the mechanisms of autophagy induced by dif?ferent amino acid deficiencies are not identical. Therefore, the aim of this paper is to summarize the process of cell autophagy regulated by different amino acids, and systematically review the molecular mechanism of cell autophagy regulated by amino acids, in order to provide a theoretical basis for precise nutritional regulation. [ Chinese Journal of Animal Nutrition, 2019, 31(10) :4494?4501]关键词
氨基酸/细胞/自噬/分子机制Key words
amino acids/cells/autophagy/molecular mechanism分类
农业科技引用本文复制引用
宋志文,金成龙,严会超,王修启..氨基酸调控细胞自噬的分子机制[J].动物营养学报,2019,31(10):4494-4501,8.基金项目
十三五国家重点研发计划(2018YFD0500403) （2018YFD0500403）
国家自然科学基金项目(31872389) （31872389）
