江苏大学学报（医学版）2019，Vol.29Issue(5)：419-424,6.DOI:10.13312/j.issn.1671-7783.y190084
脑微出血与急性缺血性卒中后抑郁的相关性
The correlation between cerebral microbleeds and poststroke depression in acute ischemic stroke
摘要
Abstract
Objective: To investigate the correlation between cerebral microbleeds (CMBs) and post-stroke depression (PSD) in acute ischemic stroke. Methods: The clinical data of hospitalized patients with first time or recurrence acute ischemic stroke were collected from department of neurology. Baseline demographic and clinical information on admission were recorded. Head MRI images were completed within 3 days on admission. The patients were divided into lobes, deep and posterior fossa (brainstem and cerebellum) groups according to ischemic location, and the total number of CMBs in each site was recorded. PSD was diagnosed according to depression criteria at the end of 3 month following-up. The patients enrolled were divided into the PSD and non-PSD group. Multivariate Logistic regression analysis was used to analyze the correlation between CMBs and post-stroke depression. Results: A total of 203 cases were enrolled, and 67 cases in PSD group and 136 cases in non-PSD group. Univariate analysis showed that years of education, baseline NIHSS score, 3-monthe MMSE score, 3-month LSNS score, cerebral microbleed in frontal lobe, deep brain stem and frontal lobe acute cerebral infarction were significantly correlated with the occurrence of PSD（all P＜0.05）. Multivariate Logistic regression analysis showed, after adjusting for relevant factors, cerebral microbleeds in deep and brainstem (OR=2.091, 95% CI=1.061-4.138, P=0.036; OR=2.235, 95% CI=1.179-4.587, P=0.031) had independent correlation with the occurrence of PSD. Baseline NHISS score (OR=1.174, 95% CI=1.008-1.346, P=0.041) and acute prefrontal lobe cerebral infarction (OR=4.326, 95% CI=1.074-14.371, P=0.045) were also independently correlated with the occurrence of PSD. Conclusion: In patients with mild to moderate acute ischemic stroke, microbleeds in the brain stem and deep brain is an in dependent risk factor for poststroke depression after 3 months of ischemic stroke.关键词
脑微出血/卒中后抑郁/脑梗死/急性缺血性卒中/血脑屏障Key words
Cerebral microbleeds/ post-stroke depression/ cerebral infarction/ acute ischemic stroke/ blood brain barrier分类
医药卫生引用本文复制引用
胡佳,周志明,杨倩,韩剑,颜燕..脑微出血与急性缺血性卒中后抑郁的相关性[J].江苏大学学报（医学版）,2019,29(5):419-424,6.基金项目
南京市医学科技发展项目(ZKX16064) （ZKX16064）
