临床神经病学杂志2019，Vol.32Issue(5)：364-367,4.
甲状腺病态综合征在急性脑梗死预后预测中的意义
Prognostic significance of euthyroid sick syndrome in acute cerebral infarction
费菲 1徐勤荣 1孔凡贞 2冯红选 1桂千 1董晓峰 1程庆璋 1吴冠会1
作者信息
- 1. 215002 南京医科大学附属苏州医院(苏州市立医院)神经内科
- 2. 苏州市广济医院(苏州大学附属广济医院)临床心理科
- 折叠
摘要
Abstract
To investigate the prognostic significance of thyroid hormone levels among patients with euthyroid sick syndrome ( ESS) for the different TOAST ischemic stroke subtypes. Methods The clinical data of Suzhou Municipal Hospital patients with cerebral infarction were collected from 2012 to 2016. TOAST classification was confirmed with MRA or CTA or DSA imaging. The modified Rankin Score ( mRS) was assessed one-year post-stroke via telephone. Correlation between potential etiological factors and ESS incidence or prognostic outcomes were analyzed. Results The levels of triiodomethylamine, free triiodomethylamine, thyroxine and thyroid hormone in ESS group were significantly lower than those in control group (all P<0.05). The proportion of major atherosclerosis and arterioocclusion were significantly higher in ESS group than those in control group (P=0.005, P=0.010). Logistic regression analysis showed that advanced age, hypoalbuminemia and high NIHSS score were the independent risk factors for the occurrence of ESS in patients with acute cerebral infarction (OR=1.046, OR=0.883, OR=1.125;all P<0.05); Age and NIHSS score of acute cerebral infarction were positively correlated with mRS score (OR=1.049, OR=1.329; all P<0.05). Conclusions ESS can predict poor prognosis of cerebral infarction with large artery atherosclerosis or small artery occlusion. Advanced age and severe neurological deficits are independent risk factors for ESS incidence and poor prognosis of cerebral infarction. Hypoalbuminemia is an independent risk factor for cerebral infarction concomitant with ESS.关键词
脑梗死/甲状腺病态综合征/TOAST分型/低白蛋白血症Key words
cerebral infarction/euthyroid sick syndrome/TOAST classification/hypoalbuminemia分类
医药卫生引用本文复制引用
费菲,徐勤荣,孔凡贞,冯红选,桂千,董晓峰,程庆璋,吴冠会..甲状腺病态综合征在急性脑梗死预后预测中的意义[J].临床神经病学杂志,2019,32(5):364-367,4.
