中国卒中杂志2019，Vol.14Issue(8)：750-755,6.DOI:10.3969/j.issn.1673-5765.2019.08.003
基于多对比度磁共振血管壁成像技术对前循环症状性颅内外动脉粥样硬化斑块特征的对比研究
Characteristics of Symptomatic Intra- and Extracranial Atherosclerotic Plaques in Anterior Circulation Based on Multi-contrast Magnetic Resonance Vascular Wall Imaging
摘要
Abstract
Objective To compare the characteristics of intra- and extracranial plaques using 3D multi-contrast magnetic resonance vessel wall imaging in patients with symptomatic intra- and extracranial atherosclerotic diseases. Methods The data of patients with symptomatic intra-and extracranial carotid artery culprit plaques identified by MR vessel wall imaging were retrospectively analyzed. The distribution, burden and components of plaques were analyzed. The plaque burden including the maximum wall thickness (Max WT), plaque length and vessel stenosis were measured. Plaque components such as lipid-rich necrotic core (LRNC), intraplaque hemorrhage (IPH) and calcification on MRI were evaluated. The imaging characteristics of plaques between intracranial and extracranial arteries were compared. Results In total, 45 patients were recruited and 203 atherosclerotic plaques were detected, including 156 extracranial plaques (76.8%) and 47 intracranial plaques (23.2%). Max WT [(3.2±1.0) mm vs (1.9±0.4) mm, P<0.001] and plaque length [10.7 (7.5-13.7) mm vs 4.3 (2.6-6.3) mm, P<0.001] of extracranial plaques were significantly larger than that of intracranial plaques. Stenosis degree [28.0 (20.0-38.5)% vs 18.8 (10.8-30.5)%, P<0.001] of intracranial plaques were significantly larger than that of extracranial plaques. Compared with intracranial plaques, extracranial plaques showed more higher rate of LRNC (66.0% vs 21.3%, P<0.001) and lower rate of IPH (13.5% vs 27.7%, P=0.027). Conclusions For patients with atherosclerotic culprit plaques and symptomatic intracranial and extracranial artery diseases, extracranial plaques commonly have greater Max WT, higher rate of LRNC, less severe stenosis and lower rate of IPH than intracranial plaques.关键词
动脉粥样硬化/斑块成分/斑块负荷/颅内动脉/颅外动脉Key words
Atherosclerosis/Plaque component/Plaque burden/Intracranial artery/Extracranial artery引用本文复制引用
许艺兰,李睿,崔园园,郑卓肇,赵锡海..基于多对比度磁共振血管壁成像技术对前循环症状性颅内外动脉粥样硬化斑块特征的对比研究[J].中国卒中杂志,2019,14(8):750-755,6.基金项目
国家自然科学基金青年科学基金项目(81801694)北京市医院管理局青年人才培养"青苗"计划(QML20180902) （81801694）
