中国卒中杂志2019，Vol.14Issue(8)：760-764,5.DOI:10.3969/j.issn.1673-5765.2019.08.005
缺血性卒中后焦虑抑郁与认知功能障碍的关系研究
Relationship of Post-stroke Depression and Anxiety with Cognitive Impairment
摘要
Abstract
Objective To explore the relationship of post-stroke depression and anxiety with cognitive impairment. Methods 98 patients with first ischemic stroke who were admitted to the First Hospital of Handan from January 2017 to March 2018 were selected. 50 inpatients with non-stroke in the same period were chosen as control group.The patients of the two groups were assessed using the following scales within 2 days after hospitalization, including Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD), activity of daily living scale (ADL), Montreal cognitive assessment (MOCA) and NIHSS. The cognitive impairment, anxiety and depression in both groups were analyzed. The correlation analysis of ADL, MoCA, NIHSS and HAMA, HAMD scores were performed. Results 62 (63.3%) patients in stroke group were diagnosed with cognitive dysfunction, 53 (54.1%) patients with anxiety, and 42 (42.9%) patients with depression; while in control group, 14 (28%) cases with cognitive dysfunction, 17 (34.0%) ones with anxiety, and 9 (18.0%) ones with depression. The MoCA and ADL scores in stroke group were both lower than that in control group, and the differences were statistically significant. The correlation analysis of HAMA and ADL, MoCA, NIHSS score showed that the correlation coefficients r=-0.526 (P<0.001), r=-0.592 (P<0.001) and r=0.412 (P<0.001), respectively; the correlation coefficients of HAMD score and ADL, MoCA, NIHSS were r=-0.490 (P<0.001), r=-0.571 (P<0.001) and r=0.606 (P<0.001), respectively. The correlation coefficients of ADL, MoCA and NIHSS were r=0.933 (P<0.001) and r=-0.842 (P<0.001). The correlation coefficient of MoCA and NIHSS wasr=-0.911 (P<0.001). Conclusions The incidence of anxiety and depression after ischemic stroke were higher, and they were both correlated with cognitive impairment. The more severe post-stroke anxiety and depression, the more serious the neurological deficit and the worse the activity of daily living.关键词
缺血性卒中/焦虑/抑郁/认知功能障碍Key words
Ischemic stroke/Anxiety/Depression/Cognitive impairment引用本文复制引用
李世文,陈红霞,邱晓雪,朱琳,武一平,林杰..缺血性卒中后焦虑抑郁与认知功能障碍的关系研究[J].中国卒中杂志,2019,14(8):760-764,5.基金项目
河北省卫生和计划生育委员会课题项目——睡眠障碍及焦虑抑郁与轻度认知功能障碍的相关性研究(20160377) （20160377）
