摘要
Abstract
Objective To explore the risk factors of preoperative rebleeding of ruptured intracranial aneurysms, to provide reference for preventing aneurysm rebleeding. Methods This is a retrospective case-control study. A total of 450 cases diagnosed with ruptured intracranial aneurysm patients were included. According to whether or not there was rebleeding before surgery, all the patients were divided into non-rebleeding group and rebleeding group. Multivariate logistic regression analysis was used to analyze the risk factors of aneurysm rebleeding. Results The rate of preoperative rebleeding of ruptured intracranial aneurysms reached up to 23.56% (106/450). Logistic regression analysis showed that the following factors of hypertension ( OR 4.221, 95% CI 2.969-5.472, P<0.001), cerebral angiospasm (OR 2.015, 95% CI 1.274-2.756, P=0.005), epilepsy ( OR 3.093, 95% CI 1.980-4.206, P<0.01), DSA examination ( OR 1.684, 95% CI 1.103-2.265, P=0.002), irregular shape of aneurysm (OR 2.465, 95% CI 1.887-3.042, P<0.001), aneurysm diameter≥10 mm ( OR 3.046, 95% CI 2.060-4.031, P<0.001), severe cough ( OR 3.594, 95% CI 2.447-4.741, P<0.001), abnormal mood fluctuation ( OR 2.756, 95% CI 1.928-3.585, P=0.002), earlier moving or out-of-bed activity ( OR 4.226, 95% CI 2.769-5.683, P<0.001), forced defecation ( OR 2.451, 95% CI 1.810-3.092, P<0.001) and Hunt-Hess grade ( OR 1.073, 95% CI 1.031-1.114, P<0.001) were all dependent risk factors of rebleeding of ruptured intracranial aneurysm before surgery. Conclusions The incidence of rebleeding of ruptured intracranial aneurysm before surgery was still high, and there were many independent risk factors affecting aneurysm rebleeding. According to the risk factors, intervention measures should be taken to prevent the occurrence of aneurysm rebleeding.关键词
颅内动脉瘤/破裂动脉瘤/再出血/危险因素Key words
Intracranial aneurysm/Ruptured aneurysm/Rebleeding/Risk factor
