中风与神经疾病杂志2019，Vol.36Issue(10)：906-909,4.
脑小血管病的MRI负荷评分与卒中高危人群认知功能障碍的关系
The relationship with the Magnetic Resonance Imaging burden score of cerebral small-vessel disease and cognitive impairment in high-risk stroke population
吴卫文 1王阳 1徐俊 2陆丽霞 1陈林 1余慧 1武刚 2丁晶3
作者信息
- 1. 复旦大学附属中山医院青浦分院神经内科,上海201700
- 2. 复旦大学附属中山医院青浦分院放射科,上海201700
- 3. 复旦大学附属中山医院神经内科,上海200032
- 折叠
摘要
Abstract
Objective To explore the association between the MRI burden score of CSVD and cognitive impairment in high-risk stroke population. Method 220 cases of high-risk stroke population in community were selected as research subjects to test cognitive function and MRI changes of CSVD. The 220 patients were divided into groups according to the score of MOCA and the MRI burden score of 0,1,2 and 3~4. Results There were 77 cases with normal cognitive function with MOCA ≥26 and 143 cases with cognitive impairment with MOCA<26. There were significant differences in educa-tion,family history of stroke,smoking history(P<0. 05). The results of the different groups of MRI burden score showed that there were significant differences in age,hyperlipidemia and cognitive impairment between 3 to 4 group and 0 to 1 groups of MRI burden score (P<0. 05),and there were significant differences in the history of hypertension between 2 group and 0 to 1 group (P<0. 05). The results of Bivariate linear regression equation showed the overall cognitive func-tion,memory and language function were negatively correlated with the MRI burden score of CSVD ( β= -0. 189,95% CI-0. 298~ -0. 019,P=0. 018;β= -0. 211,95% CI -0. 396~ -0. 048,P=0. 010;β= -0. 203,95% CI -0. 358~ -0. 049,P=0. 009). Conclusions The MRI burden score of CSVD is correlated with the occurrence of cognitive impair-ment in high-risk stroke population. And there were more obvious declines in the cognitive,memory and language functions with higher CSVD scores.关键词
脑小血管病/ 认知功能障碍/ 核磁共振Key words
Cerebral small vessel diseases/ Cognitive dysfunction/ Magnetic resonance imaging分类
医药卫生引用本文复制引用
吴卫文,王阳,徐俊,陆丽霞,陈林,余慧,武刚,丁晶..脑小血管病的MRI负荷评分与卒中高危人群认知功能障碍的关系[J].中风与神经疾病杂志,2019,36(10):906-909,4.
