烟草科技2019，Vol.52Issue(10)：68-74,7.
应用人造口腔模拟挤压装置研究口含烟烟碱释放的影响因素
Study on key factors behind nicotine release from snus with a buccal cavity simulator
摘要
Abstract
In order to investigate the effects of moisture content, tobacco powder particle size and pH on the nicotine release rate in snus, an analytical instrument to simulate the nicotine release in buccal cavity was developed with an accompanied method for the in vitro release of nicotine. The snus samples were prepared according to the Swedish Match GothiaTek? standard. The in vitro release behaviors of nicotine were measured under different moisture contents, tobacco particle sizes and pH values. The results showed that: 1) Comparing with the sample at 10% moisture content, the nicotine release rate at 30% moisture content was raised by 40% within 2 min. When the moisture content was above 30% , nicotine release rate did not change significantly. 2) Within the initial 2 min, the nicotine release rate for samples with 180 μ m tobacco particle size was three times that of 1 700 μ m. 3) The nicotine in the samples could be effectively released at pH 6.7, 7.4 and 8.5. 4) The 3-factor models of nicotine release for the snus samples followed an exponential function with the fitting coefficient R2 higher than 0.95. The results of this study provide a theoretical and practical reference for the product quality and nicotine release for snus development.关键词
口含烟/口腔模拟装置/烟碱释放/含水率/烟粉粒径/pHKey words
Snus/ Buccal cavity simulator/ Nicotine release/ Moisture content/ Particle size of tobacco powder/ pH分类
轻工纺织引用本文复制引用
田永峰,杨柳,杨继,陈永宽,缪明明,刘志华,李鹏,刘泽,孙世豪,董高峰,张杰,王昆淼,段沅杏,汤建国..应用人造口腔模拟挤压装置研究口含烟烟碱释放的影响因素[J].烟草科技,2019,52(10):68-74,7.基金项目
云南中烟工业有限责任公司科技项目"新型烟草产品开发前沿技术研究及应用"(2017XY01). （2017XY01）
