数字中医药（英文）2018，Vol.1Issue(3)：191-197,7.
中医药治疗中风神经保护和促进神经再生的疗效与机制研究进展
Clinical Efficacy and Therapeutic Mechanisms of Traditional Chinese Medicine for Neuroprotection and Neurogenesis in Stroke Treatment
摘要
Abstract
Stroke is the leading cause of human disability with limited effective drugs availability. The disruption of multiple signaling pathways in stroke makes developing new drugs be difficult. Traditional Chinese medicine (TCM) has its unique advantage in targeting multiple signaling pathways with multiple components. Many TCM formulas have the potential for neuroprotection and neurogenesis, but well-designed clinical trials are insufficient and underlying mechanisms unclear. Herein, we introduce the commonly used TCM formulas for stroke treatment and selectively introduce two classic formulas, An Gong Niu Huang (AGNH) pill and Bu Yang Huan Wu Decoction (BYHWD) for neuroprotection and neurogenesis, respectively. Current scientific evidence and clinical trials indicate AGNH pill could be an effective neuroprotective formula as adjunct therapy with relative safety. On the other hand, as a representative TCM formula for post stroke disability, BYHWD could improve the neurological outcome with its neuroprotective and neurogenic effects. The underlying mechanisms could be attributed to the modulation of multiple molecular targets with its multiple components. In conclusion, TCM formulas could be potential adjunct therapies for stroke treatment. The clinical efficacies and molecular mechanisms of promoting neuroprotection and neurogenesis remain to be further studies.关键词
中风/神经保护/神经新生/中医药/补阳还五汤/安宫牛黄丸Key words
Stroke/Neuroprotection/Neurogenesis/Traditional Chinese Medicine/Bu Yang Huan Wu Decoction/An Gong Niu Huang pill引用本文复制引用
沈剑刚..中医药治疗中风神经保护和促进神经再生的疗效与机制研究进展[J].数字中医药（英文）,2018,1(3):191-197,7.基金项目
We thank for the funding support from the Hong Kong Innovation and Technology Commission ITF grant (UIM/289) （UIM/289）
Grant from National Natural Science Foundation of China (No. 31570855), and Contract Research Project of Beijing Tong Ren Tang Chinese Medicine Co. Ltd. （No. 31570855）
