中国卒中杂志2019，Vol.14Issue(9)：872-876,5.DOI:10.3969/j.issn.1673-5765.2019.09.004
急性孤立性脑桥梗死神经功能缺损进展的危险因素分析
Analysis of Risk Factors for Neurological Deficit Progression in Acute Isolated Pontine Infarction
摘要
Abstract
Objective To analyze the risk factors, etiological subtype and prognosis of neurological deficit progression in acute isolated pontine infarction (AIPI). Methods The data of AIPI patients consecutively admitted in Department of Neurology , the Second Affiliated Hospital of Xi'an Jiao Tong University from January 2015 to June 2018 were retrospectively analyzed. According to whether there was neurological deficit progression or not, all the patients were divided into progression group and non-progression group. The baseline clinical data, causative classification subtypes, incidence of vertebrobasilar dolichoectasia (VBD) and prognosis of the two groups were recorded and analyzed. Multivariate logistic regression analysis was used to analyze the risk factors of neurological deficit progression in AIPI. Results Finally, a total of 122 AIPI patients were included, with 28 cases (23.0%) in progression group and 94 cases (77.0%) in non-progression group. The rate of diabetes, dysphagia on admission and the mRS score at discharge in progression group were all higher than that in non-progression group (P<0.05). The causative classification subtypes of the two groups had statistical difference (χ2=8.739, P=0.013), the progression group had 16 cases (57.1%) of basilar artery branch disease (BABD), 2 cases (7.1%) of small artery disease (SAD) and 10 cases (35.7%) of large artery occlusive disease (LAOD). The incidence of VBD in progression group (25%) was higher than that in non-progression group (13.8%), but there was no statistical difference between the two groups (P=0.267). Compared to the non-progression group, the rate of poor prognosis in progression group significantly increased (46.4% vs 10.6%, P<0.001). Logistic regression analysis showed that dysphagia was an independent risk factor for neurological deficit progression in AIPI patients ( OR 4.610, 95% CI 1.461-14.546, P=0.009). Conclusions Diabetes, dysphagia, VBD and the BABD of causative classification subtype were associated with neurological deficit progression in AIPI patients, and dysphagia was an independent risk factor for neurological deficit progression. The incidence of poor prognosis significantly increased in AIPI patients after neurological deficit progression.关键词
急性孤立性脑桥梗死/神经功能缺损/病因分型/吞咽障碍Key words
[Key Words] Acute isolated pontine infarction/ Neurological deficit/ Causative classification/Dysphagia引用本文复制引用
姚丽,樊嘉欣,张宏,李涛,曹会芳,吴海琴,张桂莲..急性孤立性脑桥梗死神经功能缺损进展的危险因素分析[J].中国卒中杂志,2019,14(9):872-876,5.基金项目
国家自然科学基金资助项目(81971116)陕西省重点研发计划项目(2019ZDLSF01-04)陕西省自然科学基金资助项目(2016JM8139) （81971116）
