中国卒中杂志2019，Vol.14Issue(9)：877-881,5.DOI:10.3969/j.issn.1673-5765.2019.09.005
轻度血管性认知障碍影响因素分析
Influencing Factors of Mild Vascular Cognitive Impairment
摘要
Abstract
Objective To explore the influencing factors of mild vascular cognitive impairment (mVCI). Methods Patients with acute ischemic stroke within 14 days from onset who were admitted to Handan First Hospital From August 2015 to October 2018 were selected. All the patients were assessed by mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA). According to the scores, these patients were divided into mVCI group and normal cognition (NCI) group. The clinical data were compared between the two groups, using univariate analysis and multivariate logistic regression analysis were used to analyze the influencing factors of mVCI. Results Finally, a total of 205 patients were included in this study, with 97 cases in mVCI group and 108 cases in NCI group. The proportion of patients with low education (P=0.006), hypertension (P=0.032), diabetes (P=0.041) and smoking (P=0.026) in mVCI group were significantly higher than that in NCI group. The levels of plasma homocysteine (P=0.016), triglyceride (P=0.040), cholesterol (P=0.026) and Pittsburgh sleep quality index (P<0.001) were significantly higher in mVCI group than that in NCI group. Elevated plasma homocysteine level ( OR 1.139, 95% CI 1.012-1.283, P=0.031) and multivariate logistic regression analysis showed that poor sleep quality (OR 1.301, 95% CI 1.107-1.530, P=0.001) were independent risk factors for mVCI, and high education degree ( OR 0.652, 95% CI 0.434-0.978, P=0.039) was a protective factor. Conclusions Hyperhomocysteinemia and poor sleep quality are independent risk factors for mVCI, while high education degree is a protective factor for mVCI.关键词
轻度血管性认知障碍/危险因素/保护性因素Key words
[Key Words] Mild vascular cognitive impairment/ Risk factor/ Protective factor引用本文复制引用
陈红霞,邱晓雪,李世文,宋彦丽,武一平,林杰..轻度血管性认知障碍影响因素分析[J].中国卒中杂志,2019,14(9):877-881,5.基金项目
河北省卫生和计划生育委员会课题项目(20160377) （20160377）
