中国卒中杂志2019，Vol.14Issue(9)：882-888,7.DOI:10.3969/j.issn.1673-5765.2019.09.006
血清脂蛋白相关磷脂酶A2水平对颈动脉粥样硬化斑块及其稳定性预测价值的研究
Association between Serum Lipoprotein-associated Phospholipase A2 Level and Carotid Plaque Development and Vulnerability: a Cross-sectional Study
摘要
Abstract
Objective To investigate the association of serum total 1ipoprotein-associated phospholipase A2 (Lp-PLA2) level with the vulnerability of atherosclerotic carotid plaques. Methods Data of this cohort study were from Asymptomatic Polyvascular Abnormalities Community (APAC) study, which was a cross-sectional study. The data of serum Lp-PLA2 level and ultrasonographic assessment of carotid plaques were extracted and analyzed. The participants were divided into 4 groups based on the quartile of serum total Lp-PLA2 level. The multivariate logistic regression analysis was used to analyze the correlation between the serum total Lp-PLA2 level and carotid plaque development and vulnerability. Results A high Lp-PLA2 level (>159.1 ng/mL) was associated with carotid plaque vulnerability amongst the adults ( OR 2.8, 95% CI 2.0-3.8, P<0.0001). After adjusting for the relevant risk factors, the tendency still existed ( OR 1.7, 95% CI 1.2-2.5, P=0.0067). For subjects aged<60 years old, the correlation between the two variates still existed (OR 1.7, 95% CI 1.1-2.7, P=0.0142), while for subjects aged ≥60 years old, the difference of serum Lp-PLA2 level among the 4 groups had no statistical significance Conclusions An elevated serum Lp-PLA2 level was associated with carotid plaque vulnerability in adults, especially ones aged <60 years.关键词
脂蛋白相关磷脂酶A2/颈动脉/动脉粥样硬化斑块/危险因素Key words
[Key Words] Lipoprotein-associated phospholipase A2/ Carotid artery/ Atherosclerosis plaque/Risk factor引用本文复制引用
申园,王丹丹,赵性泉..血清脂蛋白相关磷脂酶A2水平对颈动脉粥样硬化斑块及其稳定性预测价值的研究[J].中国卒中杂志,2019,14(9):882-888,7.基金项目
脑出血损伤机制与干预评价研究(2018YFC1312200)北京市医院管理局"登峰"人才培养计划(DFL20150501)神经系统重大疾病创新药物临床评价技术平台建设(2017ZX09304018) （2018YFC1312200）
