中国卒中杂志2019，Vol.14Issue(9)：889-894,6.DOI:10.3969/j.issn.1673-5765.2019.09.007
不同脑白质损伤部位对老年轻度认知障碍的影响
Influence of Different Location of White Matter Lesion on Mild Cognitive Impairment in Senile Patients
胡瑞红 1柴长风 1范存秀 1毕晓莹1
作者信息
- 1. 200433 上海海军军医大学附属长海医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the influence of different location of white matter lesion (WML) on mild cognitive impairment (MCI) in senile patients. Methods A total of 200 elderly patients with WML and MCI were enrolled in WML group, and 40 healthy physical examination adults were selected as control group. WML patients were divided into paraventricular subgroup (n=64), subventricular subgroup (n=56), subcortical subgroup (n=46) and deep subgroup (n=34) according to the lesion location. The cognitive function of all subjects were evaluated using the Montreal cognitive assessment (MoCA) and mini-mental state examination (MMSE). Results The MMSE scores of WML and control group were 23.04±1.42 and 28.23±1.57, respectively (P=0.005). The MoCA scores of WML and control group were 19.91±1.55 and 25.94±2.32, respectively (P=0.001). Among the 8 items of MoCA, the visual / executive scores of deep subgroup were the lowest, the naming and abstract thinking scores of subcortical group were the lowest, the calculation score and delayed recall score of paraventricular subgroup were the lowest, and the attention score of subventricular subgroup was the lowest. The scores of the 8 items in subcortical subgroup were all lower than that in control group, the differences were all statistically significant, and the involved cognitive domains were most extensive. Conclusions Different location of WML in the elderly patients had different influence on the cognitive domains, and the involved cognitive domains in patients with subcortical WML were most extensive.关键词
脑白质损伤/老年/认知功能障碍Key words
[Key Words] Cerebral white matter lesion/ Elderly/ Cognitive dysfunction引用本文复制引用
胡瑞红,柴长风,范存秀,毕晓莹..不同脑白质损伤部位对老年轻度认知障碍的影响[J].中国卒中杂志,2019,14(9):889-894,6.
