肿瘤药学2019，Vol.9Issue(5)：710-715,6.DOI:10.3969/j.issn.2095-1264.2019.05.02
胆汁酸-肠道菌群相互作用与结直肠癌发生发展的研究进展★
Research Progress of the Interaction between Bile Acids and Gut Microbiota and Intestinal Carcinogenesis★
摘要
Abstract
Colorectal cancer is a commonly diagnosed gastrointestinal tumor. Its development is closely correlated to the genetic and en-vironmental factors. The metabolic disturbance of bile acids caused by high fat diet, as well as the dysbiosis of gut microbiota, plays a criti-cal role in intestinal tumorigenesis. We first summarized the synthesis, transport and metabolism of bile acids, and the function of bile acids receptors (such as farnesoid X receptor). This review also highlighted the interaction between bile acids and gut microbiota and its role in intestinal carcinogenesis. Thus targeting bile acids-gut microbiota axis may provide new insights into the prevention and treatment of CRC.关键词
胆汁酸/肠道菌群/结直肠癌/法尼醇X受体Key words
Bile acids/Gut microbiota/Colorectal cancer/Farnesoid X receptor分类
医药卫生引用本文复制引用
李楚荞,刘天宇,宋雪例,李晓飞,郭莲怡,王邦茂,曹海龙..胆汁酸-肠道菌群相互作用与结直肠癌发生发展的研究进展★[J].肿瘤药学,2019,9(5):710-715,6.基金项目
国家自然科学基金(81470796、81570478) （81470796、81570478）
天津市自然科学基金(17JCYBJC24900). （17JCYBJC24900）
