肿瘤药学2019，Vol.9Issue(5)：783-788,6.DOI:10.3969/j.issn.2095-1264.2019.05.17
硼替佐米皮下注射治疗多发性骨髓瘤的疗效及安全性观察
The Efficacy and Side Effects of Subcutaneous Injection of Bortezomib in the Treatment of Multiple Myeloma
孙玉娇 1许宏 1郭振清 1鞠小妍 1崔中光 1赵洪国1
作者信息
- 1. 青岛大学附属医院,山东 青岛,266000
- 折叠
摘要
Abstract
Objective To explore the clinical effects of subcutaneous injection of bortezomib on multiple myeloma and its side effects. Methods Clinical data of 166 patients with multiple myeloma treated in our hospital between January 2013 and January 2018 were analyzed. Of the patients, 117 cases got subcutaneous injection of bortezomib (SC group), and the other 49 cases got intravenous infusion of bortezomib (Ⅳ group). The curative effects and the incidence of adverse reactions of patients in the two groups were observed and compared. Results After 2 courses of treatment, the percentages of complete remission (CR) cases, of very good partial remission (VGPR) cases and of partial response (PR) cases showed no statistical differences between two groups (P>0.05), and so did they after 4 courses of treatment (P>0.05). Patients in SC group completed 3~18 courses of treatment, 8.5 courses in average, and those in Ⅳ group completed 3~16 courses of treatment, 6.6 courses in average. At the end of the treatment with bortezomib, the percentage of PR in SC group was higher than in Ⅳgroup (P<0.001). No significant difference in PFS and OS were found between two groups (P>0.05). The incidence of all grades of peripheral neuropathy (PN) and the incidence of PN above grade Ⅲ were significantly lower in SC group than in IV group (P<0.05). The incidence of infection was lower in SC group than in IV group (P<0.05). No significant differences were found in other side effects between the two groups (P>0.05). Conclusion The SC injection of bortezomib had comparable early efficacy with Ⅳ injection. It could also reduce the occurrence of PN and improve the drug safety.关键词
多发性骨髓瘤/硼替佐米/皮下注射/周围神经病变Key words
Multiple myeloma/Bortezomib/Subcutaneous injection/Peripheral neuropathy分类
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孙玉娇,许宏,郭振清,鞠小妍,崔中光,赵洪国..硼替佐米皮下注射治疗多发性骨髓瘤的疗效及安全性观察[J].肿瘤药学,2019,9(5):783-788,6.
