肿瘤预防与治疗2019，Vol.32Issue(11)：1004-1012,9.DOI:10.3969/j.issn.1674-0904.2019.11.010
软组织肉瘤临床特征分布的多中心研究
Clinical Characteristics of Soft Tissue Sarcomas:A Multicenter Study
摘要
Abstract
To analyze the clinical characteristics of soft tissue sarcomas (STS) diagnosed from different hospitals be-tween 2011 and 2015 to provide evidence-based information for further standardized diagnosis and treatment of STS. Meth-ods:Data were from 15 hospitals, including 14 tertiary hospitals and 1 level A secondary general hospital, from Beijing, Henan, Hebei, Hubei, Zhejiang, Guangdong provinces. Clinical information of patients who were newly diagnosed was col-lected from 2011 to 2015. The questionnaire was self-made and data were entered using Epidata 3. 0. Tumor sites, histologi-cal types were coded according to International Classification of Diseases for Oncology (third version). Chronological ages at first diagnosis were further classified into 18 age groups and 4 age brackets. Main therapeutics were analyzed. Results:A to-tal of 3,712 patients (1,895 males and 1,817 females) were enrolled from 15 hospitals. The most common histological sub-type of STS was gastrointestinal stromal tumor (543 cases, 14. 39% ), followed by sarcomas (not otherwise specified) (521 cases, 14. 04% ). STS could occur anywhere in the body. It could be found in connective and soft tissue (1,130 cases, 30. 44% ) in head, limbs, and pelvic and so on. New cases of STS peaked in females aged 55-59 (13. 54% ) and in males aged 60-64 (12. 98% ), respectively. The most common histological subtype of STS in 0-to-14-year-olds and 15-to-44-year-olds were rhabdomyoma and sarcoma (not otherwise specified), respectively. Gastrointestinal stromal tumor was the most common histologic subtype of STS in people aged 45-59 and over 60. The most common therapeutic was surgery, fol-lowed by chemotherapy and radiotherapy. Conclusion:Gastrointestinal stromal tumor is the most common histological sub-type of STS, especially in the elderly. Males have a later peak in age of onset. The most common therapeutic of STS was sur-gery. Standard should be further developed for the selection of therapeutics.关键词
软组织肉瘤/临床特征/年龄分布/治疗方式Key words
Soft tissue sarcomas/Clinical characteristic/Age distributions/Therapeutics分类
医药卫生引用本文复制引用
曹毛毛,曾红梅,张思维,李贺,杨之洵,陈万青,郑荣寿,王宁,贺宇彤,孙喜斌,杜灵彬,刘曙正,庹吉妤,魏矿荣..软组织肉瘤临床特征分布的多中心研究[J].肿瘤预防与治疗,2019,32(11):1004-1012,9.基金项目
科技部基础工作专项(编号:2014FY121100) （编号:2014FY121100）
中国医学科学院医学与健康科技创新工程(编号:2016-12M-2-004) This study was supported by grants from Ministry of Science and Technology of the People's Republic of Chi-na(NO.2014FY121100) and by CAMS Innovation Fund for Medical Sciences(NO.2016-12M-2-004). （编号:2016-12M-2-004）
