临床神经外科杂志2019，Vol.16Issue(6)：461-464,471,5.DOI:10.3969/j.issn.1672-7770.2019.06.001
microRNA-424表达与脑胶质瘤级别、预后、化疗敏感性的关系及其机制
Relationship between the expression of microRNA-424 and the glioma grades, prognosis and chemosensitivity and its mechanism
摘要
Abstract
Objective To investigate the relationship between microRNA-424 expression and glioma grades, prognosis, chemosensitivity , IDH1 phenotype and Ki67 expression.Methods 198 followed-up glioma patients were selected from the Chinese Glioma Genome Atlas ( CGGA).The expression of microRNA-424 in different groups of patients , and the survival time, progression-free survival time and chemotherapeutic effect of patients with different expression levels of microRNA-424 were compared.The relationship between expression of Ki 67 protein and IDH1 phenotype and microRNA-424 expression was analyzed.Results The expression of microRNA-424 was positively correlated with tumor grades.The expression of microRNA-424 increased in IDH1 wild type and Ki67 protein overexpression patients (all P＜0.05).The prognosis of patients with high expression of microRNA-424 was significantly worse than that of patients with low expression of microRNA-424, and glioma recurred more easily.The patients with low expression of microRNA-424 were more sensitive to chemotherapy.The survival time of patients with radiotherapy plus chemotherapy was significantly longer than that of patients with radiotherapy alone ( P ＝0.007 ).Conclusion MicroRNA-424 can be used as a biomarker for the diagnosis , treatment and prognosis of glioma.关键词
脑胶质瘤/microRNA-424/预后/化疗Key words
cerebral glioma/microRNA-424/prognosis/chemotherapy分类
医药卫生引用本文复制引用
梁博,梁庭毓,王芳,王小永,冯恩山..microRNA-424表达与脑胶质瘤级别、预后、化疗敏感性的关系及其机制[J].临床神经外科杂志,2019,16(6):461-464,471,5.基金项目
北京市医管局培育计划( PX2018079) （ PX2018079）
