数字中医药（英文）2019，Vol.2Issue(1)：7-18,12.DOI:10.1016/j.dcmed.2019.05.002
系统药理学方法研究猴头菇活性成分治疗阿尔茨海默病的作用机制
Systems Pharmacological Approach to Investigate the Mechanism of Hericium erinaceus for Alzheimer's Disease
摘要
Abstract
Objective To confirm evidence regarding the potential therapeutic effect of Hericium erinaceus (H.erinaceus,Hou Tou Gu,猴头菇) on Alzheimer's disease (AD) using a system pharmacological approach in silico.Methods The active compounds of H.erinaceus were screened from the TCMDatabase@Taiwan,PubMed,and Pubchem.The predicted targets of H.erinaceus were selected by using the Similarity Ensemble Approach Database and the DisGeNET database was used to screen the targets related to AD.The compound-target-AD network was built.GO analysis and Pathway enrichment analysis were used for bioinformatics analysis.Results A total of 21 kinds of H.erinaceus active compounds were screened by network pharmacology,showing 451 predicted targets of active compounds.Among them,165 targets were associated with AD,and the compounds in H.erinaceus were highly connected to AD-related signaling pathways and biological processes,such as cholinergic synaptic transmission,inflammation-related pathways and neurotrophin signaling pathway.Conclusions Our results indicate that compounds in H.erinaceus interact with multiple targets in a synergetic way and the anti-inflammatory,anti-apoptosis and synaptic transmission enhancing effects of H.erinaceus might contribute to its major therapeutic effects on Alzheimer's disease.关键词
系统药理学/猴头菇/阿尔兹海默病/系统分析Key words
Systems pharmacology/Hericium erinaceus (Hou Tou Gu,猴头菇)/Alzheimer's disease/In silico引用本文复制引用
GunterP.Eckert,宋祯彦,成绍武..系统药理学方法研究猴头菇活性成分治疗阿尔茨海默病的作用机制[J].数字中医药（英文）,2019,2(1):7-18,12.基金项目
We thank for the funding support from the Sino-German Center for Research Promotion (GZ 1408),Talent Recruitment Project from the National Administration of Foreign Affairs (20174300030) （GZ 1408）
