数字中医药（英文）2019，Vol.2Issue(3)：157-165,9.DOI:10.1016/j.dcmed.2019.12.004
枸杞子配伍丹参对RCS(rdy-/-,p-/-)视网膜色素变性大鼠 虚中夹瘀证的干预研究
Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention Study
摘要
Abstract
Objective To investigate the effects of Lycii Fructus (LF, Gou Qi Zi, 枸杞子) and Salviae Miltiorrhizae Radix Ex Rhizoma (SM, Dan Shen, 丹参) on the syndrome of deficiency with blood stasis in the RCS (rdy-/-, p-/-) rats with retinitis pigmentosa (RP). Methods A total of 32 RCS (rdy-/-, p-/-) rats were divided into 4 groups (equal amounts of female and male rats in each group):model group treated with 0.9％ normal saline, LF group treated with LF formula granules, SM group treated with SM formula granules, and LF and SM (L·S) group treated with LF and SM formula granules. Eight RCS (rdy +/ +, p +/ +) rats (4 males and 4 females) were treated with 0.9％ normal saline to serve as blank group. The contents of E2, PG, P-Selectin, plasma viscosity, whole blood relative index of the high shear rate and fibrinogen content in plasma, and the content of cAMP and cGMP in retinal homogenate were detected. The retina was evaluated by hematoxylin-eosin staining. Results The contents of E2, PG, P-Selectin, plasma viscosity, whole blood relative index of the high shear rate, and fibrinogen content in the plasma of L·S group significantly differed from those of model group (P < 0.01), but were similar to those of blank group. The contents of cAMP and cGMP in the retinal homogenate of L·S group significantly differed from those in model group (P < 0.01) but were similar to those in blank group (P > 0.05). Conclusions LF and SM can effectively treat retinitis pigmentosa by ameliorating the syndrome of deficiency with blood stasis.关键词
视网膜色素变性/枸杞子/丹参/虚中夹瘀证/RCS(rdy-/-,p-/-)大鼠Key words
Retinitis pigmentosa (RP)/Lycii Fructus (Gou Qi Zi/枸杞子)/Salviae Miltiorrhizae Radix Ex Rhizoma (Dan Shen/丹参)/Syndrome of deficiency with blood stasis/RCS (rdy-/-/p-/-) rat引用本文复制引用
徐剑,杨毅敬,覃艮艳,周亚莎,彭俊,彭清华..枸杞子配伍丹参对RCS(rdy-/-,p-/-)视网膜色素变性大鼠 虚中夹瘀证的干预研究[J].数字中医药（英文）,2019,2(3):157-165,9.基金项目
We thank for the funding support from the National Natural science Foundation of China Funding Project (No. 81804150), Hunan Provincial Natural Science Funding Project (No. 2019JJ40226), National Key Discipline of TCM Diagnostics Foundation Funding Project (No. 2015ZYZD02), Hunan Provincial Department of Education Innovation Platform Open Funding Project (No. 16K065), Chinese Medicine Key Laboratory of Prevention and Treatment of Disease in Hunan Province (No. 2017TP1018), Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese Medicine (No. 2018TP2008), and Changsha Science and Technology Plan Project. （No. 81804150）
