数字中医药（英文）2019，Vol.2Issue(3)：166-192,27.DOI:10.1016/j.dcmed.2019.12.005
天然产物酮及其苷类成分抗氧化性及其他药用价值的最新研究进展
Antioxidant Nature Adds Further Therapeutic Value: An Updated Review on Natural Xanthones and Their Glycosides
摘要
Abstract
Plants have so much to offer as far as the discovery of new bioactive molecules is concerned. Among the several classes of phytochemicals, xanthones offer greater structural diversity and pharmacological value. They are variable but definitely antioxidant in nature. Thus they are attractive targets for natural product and medicinal chemists. Xanthones and their glycosides possess broad spectrum interesting biological activities, such as cytotoxic, anti-inflammatory, antioxidant, anti-bacterial, neuroprotective, anti-HIV, enzyme inhibition, and hypoglycemic. The radical scavenging ability of these molecules accounts for most of their added therapeutic values. This paper intended to serve as a guide for future endeavors in quest for these molecules. Structure-Activity Relationship (SAR) and mechanism of action is given for better understanding of their role as pharmacological agents. The most recent advances in the isolation of bioactive xanthones and their glycosides were presented here. This paper will assist in directed approaches towards the discovery of analogues of xanthones.关键词
酮/酮苷/抗氧化/自由基清除/酮二聚体/酮三聚体Key words
Xanthones/Xanthone glycosides/Antioxidant/Radical scavenging/Xanthone dimers/Xanthone trimers引用本文复制引用
ZAFARSalman,翦雨青,李斌,彭彩云,CHOUDHARY Muhammad Iqbal,RAHMAN Atta-ur,王炜..天然产物酮及其苷类成分抗氧化性及其他药用价值的最新研究进展[J].数字中医药（英文）,2019,2(3):166-192,27.基金项目
We thank for the funding support from the National Natural Science Foundation of China (No. 81673579), Hunan Province Universities 2011 Collaborative Innovation Center of Protection and Utilization of Hu-Xiang Chinese Medicine Resources, and Hunan Provincial Key Laboratory of Diagnostics in Chinese Medicine. （No. 81673579）
