肿瘤预防与治疗2019，Vol.32Issue(12)：1099-1105,7.DOI:10. 3969／j. issn. 1674-0904. 2019. 12. 007
123例甲状腺髓样癌患者的预后分析*
Prognosis of 123 Patients with Medullary Thyroid Carcinoma
摘要
Abstract
Objective: To investigate prognostic factors for patients with medullary thyroid carcinoma (MTC). Methods:Clinical information and follow-up data of 123 patients with MTC treated in Yunnan Cancer Hospital and Sun Yat-sen Univer-sity Cancer Center between January 1,1995 and December 31, 2015 were retrospectively analyzed with respect to mortality and survival rates by using Kaplan-Meier survival analysis and Cox regression model. Results: The 5-year, 10-year and 15-year overall survival rates were 91. 6% , 77. 9% and 63. 4% % , respectively, for all patients. Univariate analysis showed that age, sex, preoperative serum calcitonin level, primary tumor size, local infiltration, cTNM stage, distant metastasis and surgery affected prognosis of patients. Cox regres-sion analysis showed that age, gender, primary tumor size, cTNM stage, distant metastasis and receiving surgery were inde-pendent prognostic factors for MTC patients. Conclusion: MTC patients aged <40 years had a better prognosis compared to those aged ≥40 years. Male, preoperative serum calcitonin level≥1000 pg／mL, primary tumor size >4 cm, local infiltra-tion, cTNM stage and distant metastasis were factors of unfavorable prognosis for patients with MTC. However, surgical treat-ment can significantly improve the prognosis of patients with MTC.关键词
甲状腺髓样癌/血清降钙素/预后.Key words
Medullary thyroid carcinoma/Serum calcitonin/Prognosis分类
医药卫生引用本文复制引用
王士琪,储红映,赵再礼,钟兆铭,秦汝佳,王学敏,齐潇,杨安奎,孙传政..123例甲状腺髓样癌患者的预后分析*[J].肿瘤预防与治疗,2019,32(12):1099-1105,7.基金项目
国家自然科学基金(编号:81560470,81773 127) （编号:81560470,81773 127）
云南省中青年学术技术带头人后备人才专项经费(编号:2015HB086) （编号:2015HB086）
云南省医学领军人才专项经费(编号:L-2017) This study was supported by National Natural Science Foundation of China (NO. 81560470, 81773127), Special funds for Reserve Talents of Young and Middle-Aged Academic and Technical Leaders in Yunnan ( NO. 2015HB086) and by grants from Health Commission of Yunnan Province ( NO. L-2017). （编号:L-2017）
