中国卒中杂志2019，Vol.14Issue(11)：1095-1100,6.DOI:10.3969/j.issn.1673-5765.2019.11.004
MTHFR C677T基因多态性与脑小血管病认知功能障碍的相关性研究
Correlation between MTHFR C677T Gene Polymorphism and Cognitive Impairment in Patients with Cerebral Small Vessel Disease
汪明玉 1张立辉 2周浩 3赵勇1
作者信息
- 1. 1261000 潍坊潍坊市人民医院神经内科
- 2. 潍坊市人民医院急诊内科
- 3. 潍坊医学院附属医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the correlation between MTHFR C677T gene polymorphism and cognitive impairment in patients with cerebral small vessel disease (CSVD). Methods This was a retrospective study which included the CSVD outpatients and inpatients in Department of Neurology,Weifang People's Hospital between December 2017 to March 2019. Based on the Montreal cognitive assessment (MoCA) and clinical dementia rating (CDR) score, the patients were divided into three groups: normal cognition group, mild cognitive impairment group and dementia group. The level of homocysteine (Hcy), and MTHFR C677T phenotype were measured. The relationship between cognitive function and Hcy or MTHFR C677T phenotype were analyzed by comparing the above data among three groups. Results A total of 130 CSVD patients were enrolled into this study, including 87 males (66.9%), and with 63 patients in normal cognition group, 35 patients in mild cognitive impairment group and 32 patients in dementia group. The Hcy level in dementia group was significantly higher than that in mild cognitive impairment group (P<0.001) and normal cognition group (P<0.001). The Hcy level in mild cognitive impairment group was significantly higher than that in normal cognition group (P<0.001). The level of Hcy was positively correlated with cognitive decline (r=0.626, P<0.001). The frequency of C677T MTHFR mutation (C→T) genotype was positively correlated with cognitive decline (r=0.359, P=0.001). The frequency of T allele was positively correlated with cognitive decline (r=0.273, P<0.001). Conclusions MTHFR 677 C→T gene mutation was associated with cognitive decline, and it can be used as an early serum predictor for cognitive impairment in CSVD.关键词
脑小血管病/5,10-亚甲基四氢叶酸还原酶/同型半胱氨酸/认知功能Key words
Cerebral small vessel disease/5,10-methylenetetrahydrofolate reductase/Homocysteine/Cognitive function引用本文复制引用
汪明玉,张立辉,周浩,赵勇..MTHFR C677T基因多态性与脑小血管病认知功能障碍的相关性研究[J].中国卒中杂志,2019,14(11):1095-1100,6.
