中国卒中杂志2019，Vol.14Issue(11)：1106-1111,6.DOI:10.3969/j.issn.1673-5765.2019.11.006
穿支动脉疾病型脑梗死进展性运动障碍的相关因素分析及预后研究
Analysis on Factors of Progressive Motor Dysfunction and Prognosis in Patients with Cerebral Infarction due to Penetrating Artery Disease
周娟 1石富铭 1陈书阁 1张丽文 1董立平 1王铁军1
作者信息
- 1. 102600 北京北京市大兴区人民医院神经内科
- 折叠
摘要
Abstract
Objective To analyze the risk factors of progressive motor dysfunction (PMD) in patients with cerebral infarction due to perforating artery disease (PAD). Methods Patients with PAD cerebral infarction diagnosed by MRI were divided into PMD group and non-PMD Group. The demographic data, vascular risk factors, lesions characteristics, laboratory test result, prognosis and stroke recurrence at 3 and 6 months were compared between the two groups. Multivariate analysis was used to determine the independent risk factors for PMD. Results A total of 287 patients with PAD were enrolled in this study, including 95 patients with PMD and 192 patients with non-PMD. The males (P=0.03), smoking (P=0.04), the glycated hemoglobin (P<0.001), homocysteine (P=0.02), D-dimer (P=0.01) and infarct diameter (P<0.001) were all significantly higher in PMD group than that in non-PMD Group. There was no significant difference in the NIHSS scores at admission between the two groups, but the NIHSS scores at discharge in PMD group was higher than that in non-PMD group (7.69±1.87 vs 2.13±0.49, P<0.001). The rate of good prognosis at 3 months in PMD group was lower than that in non-PMD Group (55.7% vs 70.8%, P=0.01), while the two groups had no statistical difference at 6 months. There were no significant difference in recurrent cerebral infarction at 3 and 6 months between the two groups. Multivariate analysis showed that high glycated hemoglobin level ( OR 1.083, 95% CI 1.062-1.105, P=0.03) and large infarct diameter ( OR 1.051, 95% CI 1.030-1.073, P=0.01) were independent risk factors for PMD. Conclusions Of patients with cerebral infarction due to PAD, the patients occurring PMD had more severe neurological function deficit and worse prognosis at 3 months. Glycated hemoglobin and infarct diameter can be used as predictors for PMD.关键词
穿支动脉疾病/进展性运动障碍/预后Key words
Penetrating artery disease/Progressive motor dysfunction/Prognosis引用本文复制引用
周娟,石富铭,陈书阁,张丽文,董立平,王铁军..穿支动脉疾病型脑梗死进展性运动障碍的相关因素分析及预后研究[J].中国卒中杂志,2019,14(11):1106-1111,6.
