中国卒中杂志2019，Vol.14Issue(11)：1140-1145,6.DOI:10.3969/j.issn.1673-5765.2019.11.012
血清生物标志物与脑小血管病关系研究进展
Progress of Relationship between Serum Biomarkers and Cerebral Small Vessel Disease
摘要
Abstract
It is currently believed that the main mechanism of cerebral small vessel disease (CSVD) is vascular endothelial injury, which is closely related to inflammation. Serum endothelial injury and inflammatory biomarkers are the most direct and simple methods to reflect endothelial injury. Studies on biomarkers will help us to further understand the pathogenesis of CSVD. Many studies have shown that inflammatory and endothelial injury biomarkers are closely related to the occurrence and development of CSVD. In addition, the relationship between inflammation and CSVD may be affected by race, genetics, and etc. This article reviewed the progress of relationship between serum vascular endothelial injury markers, inflammatory markers and different imaging markers of CSVD.关键词
脑小血管病/内皮细胞/炎症/生物标志物Key words
Cerebral small vessel disease/Endothelial cell/Inflammation/Biomarker引用本文复制引用
钟曦,王伊龙..血清生物标志物与脑小血管病关系研究进展[J].中国卒中杂志,2019,14(11):1140-1145,6.基金项目
国家自然科学基金委员会杰出青年科学基金项目(81825007)北京高校卓越青年科学家计划项目(BJJWZYJH 01201910025030)科技部"十三五"国家重点研发计划"症状性颅内外大动脉狭窄复发进展预测模型与干预策略研究"(2017YFC1307900)北京市科学技术委员会"动脉粥样硬化性颅内动脉狭窄的他汀药物治疗研究"(D171100003017001)北京市优秀人才培养资助青年拔尖团队(2016000021223TD03) （81825007）
