中国卒中杂志2019，Vol.14Issue(11)：1146-1152,7.DOI:10.3969/j.issn.1673-5765.2019.11.013
脑小血管病脑白质高信号与认知障碍的关系研究进展
Advances in the Relationship between White Matter Hyperintensity and Cognitive Impairment in Cerebral Small Vessel Disease
摘要
Abstract
Cerebral small vascular disease (CSVD) is one of the most common age-related cerebrovascular diseases. White matter hyperintensity (WMH) of presumed vascular origin is one of the imaging markers of CSVD. The prevalence of WMH is extremely high, and which is closely related to the occurrence and development of cognitive impairment. However, the heterogeneity of imaging manifestations and clinical symptoms of WMH brings some difficulties to early detection and diagnosis. What’s more, the potential mechanism for disease development is not clear, so it leads to a relative lag in prevention and treatment of these diseases. This paper reviewed the current state of research on the mechanisms of cognitive impairment in the development of WMH from pathology, imaging and biology, and summarized the current treatment strategies, and raised some research objectives and directions in the next, for example, to establish the biomarkers and prediction model for assessing prognosis, to explore pathophysiological mechanism of WMH development, and find new potential targets for early intervention.关键词
脑小血管病/脑白质高信号/认知障碍Key words
Cerebral small vascular disease/White matter hyperintensity/Cognitive impairment引用本文复制引用
王兴,陈奕奕,王伊龙..脑小血管病脑白质高信号与认知障碍的关系研究进展[J].中国卒中杂志,2019,14(11):1146-1152,7.基金项目
国家自然科学基金委员会杰出青年科学基金项目(81825007)北京高校卓越青年科学家计划项目(BJJWZYJH 01201910025030)科技部"十三五"国家重点研发计划"症状性颅内外大动脉狭窄复发进展预测模型与干预策略研究"(2017YFC1307900)北京市科学技术委员会"动脉粥样硬化性颅内动脉狭窄的他汀药物治疗研究"(D171100003017001)北京市优秀人才培养资助青年拔尖团队项目(2016000021223TD03) （81825007）
