中国卒中杂志2019，Vol.14Issue(11)：1190-1193,4.DOI:10.3969/j.issn.1673-5765.2019.11.022
骨形态发生蛋白-7对脑梗死神经保护作用的研究进展
Advances in the Protective Effects of BMP-7 on Neurons in Cerebral Infarction
康凯 1佡剑非1
作者信息
- 1. 110004 沈阳中国医科大学附属盛京医院神经内科
- 折叠
摘要
Abstract
Cerebral infarction is one of the common cerebrovascular diseases with high mortality and disability rate. Therefore, it is of great significance to study the development and treatment of cerebral infarction. The intervention measures in acute phase of cerebral infarction can directly affect the patient's prognosis. Studies have showed that the expression of bone morphogenetic protein (BMP)-7 was up-regulated in the case of cerebral ischemia and hypoxia. The role of BMP-7 in cerebral infarction was very complex. In animal experiment, BMP-7 can not only promote motor neurons recovery and increase neuronal ischemic tolerance, but also inhibit apoptosis and weaken oxidative stress, so it plays an important role in protecting ischemic brain tissue and reducing infarction volume, which can provide a new direction for the treatment of cerebral infarction.关键词
脑梗死/骨形态发生蛋白-7/星型胶质细胞/细胞凋亡/氧化应激Key words
Cerebral infarction/Bone morphogenetic protein-7/Star glial cell/Apoptosis/Oxidative stress引用本文复制引用
康凯,佡剑非..骨形态发生蛋白-7对脑梗死神经保护作用的研究进展[J].中国卒中杂志,2019,14(11):1190-1193,4.
