国际医药卫生导报2019，Vol.25Issue(23)：3855-3856,3877,3.DOI:10.3760/cma.j.issn.1007-1245.2019.23.011
来曲唑应用于青春早中期男童对其特性和线性生长的影响
Effect of letrozole on characteristics and linear growth of boys in early and middle youth period
摘要
Abstract
Objective To analyze the effect of aromatase inhibitor letrozole on the chatacteristics and linear growth of boys in early and middle youth period.Methods Thirty children in early-middle youth period who were to be impaired in adult height and treated in our hospital from January,2016 to January,2018 were enrolled as a study group.They were treated with letrozole,1.5 mg/m2 per day.And 30 healthy boys in the early and middle youth stage taking physical examination during the same time period were selected as a control group,and took no drug intervention.The growth characteristics and linar growth changes of the two groups before treatment and after 1 year's treatment were compared.Results There were no statistical differences in bone age,age,BMI,testicular volume,and height between the study group and the control group before the intervention(all P ＞ 0.05).After the intervention,the bone age of the study group was significantly inhibited(P ＜ 0.05); the testicular volume of the study group was(7.3±2.8)ml,which was significantly higher than that of the control group [(4.5±1.2)ml,P＜ 0.05]; The study group's predicted adult height and insulin growth factor 1(IGF-1)were significantly different from the control group's(both P ＜ 0.05).Conclusion The used of letrozole in boys in early and middle youth stage can effectively inhibit bone age,improve their fìnal height and achieve their linear growth.关键词
生长特性/来曲唑/骨骼生长/芳香化酶抑制剂/线性生长Key words
Growth characteristics Letrozole/Bone growth/Aromatase inhibitor/Linear growth引用本文复制引用
彭子俊..来曲唑应用于青春早中期男童对其特性和线性生长的影响[J].国际医药卫生导报,2019,25(23):3855-3856,3877,3.基金项目
佛山市卫生和计生局项目(20190001) Project of Foshan Bureau of Health and Family Planning (20190001) （20190001）
