中国卒中杂志2019，Vol.14Issue(12)：1209-1213,5.DOI:10.3969/j.issn.1673-5765.2019.12.003
静脉溶栓联合血管内治疗在前循环大血管狭窄导致的低灌注性脑梗死患者中的疗效和安全性观察
Intravenous Thrombolysis Combined with Endovascular Treatment for Hypoperfusion Cerebral Infarction Caused by Anterior Circulation Large Vessel Stenosis
摘要
Abstract
preliminarily observe the efficacy and safety of intravenous thrombolysis combined with endovascular treatment in patients with hypoperfusion cerebral infarction caused by anterior circulation large vessel stenosis. Methods Data of consecutive patients with hypoperfusion cerebral infarction caused by anterior circulation large vessel stenosis from Liaocheng Third People's Hospital between March 2017 and March 2019 were retrospectively analyzed. All enrolled patients received intravenous alteplase combined with endovascular treatment (including mechanical thrombectomy and/or intra-arterial thrombolysis and/or balloon angioplasty and/or stenting), and were followed up for 2 weeks, 1 month and 3 months after the procedure. Results A total of 40 patients successfully completed intravenous thrombolysis combined with endovascular treatment, with 24 (60%) males and a mean age of 70±4 (range 60-80) years old. The postoperative stenosis degree of target vessel significantly improved compared with that before operation (median: 18% vs 86%, P<0.01). The median scores of NIHSS and mRS at 2 weeks, 1 and 3 months after treatment were significantly lower than that before treatment (all P<0.05). Among 40 patients, only one (2.5%) patient had massive cerebral infarction and brain herniation, and another (2.5%) had symptomatic intracranial hemorrhage on the next day after operation. Conclusions Intravenous thrombolysis combined with endovascular treatment for hypoperfusion cerebral infarction caused by anterior circulation large vessel stenosis may be effective and safe.关键词
静脉溶栓/血管内治疗/前循环/低灌注/脑梗死Key words
Intravenous thrombolysis/Endovascular treatment/Anterior circulation/Hypoperfusion/Cerebral infarction引用本文复制引用
张霞,佟旭,张斌..静脉溶栓联合血管内治疗在前循环大血管狭窄导致的低灌注性脑梗死患者中的疗效和安全性观察[J].中国卒中杂志,2019,14(12):1209-1213,5.基金项目
科技部"十三五"国家重点研发计划(2016YFC1301501)中国博士后科学基金面上资助项目(2019M650773) （2016YFC1301501）
