中国卒中杂志2019，Vol.14Issue(12)：1214-1219,6.DOI:10.3969/j.issn.1673-5765.2019.12.004
弗明汉危险评分在无症状老年人颈动脉易损斑块筛查中的价值研究
The Value of Framingham Risk Score for Screening Carotid Vulnerable Atherosclerotic Plaques in the Asymptomatic Elderly
摘要
Abstract
investigate the value of Framingham risk score (FRS) in screening carotid vulnerable atherosclerotic plaques in the asymptomatic elderly (≥60 years old). Methods FRS of every subject was calculated and the MR imaging characteristics of carotid atherosclerotic plaques on 3D MR vessel wall imaging were evaluated. All patients were divided into vulnerable plaque group and non-vulnerable plaque group based on the imaging results. FRS was compared between the two groups. Univariate logistic regression was used to calculate the OR and 95% CI of FRS in determining carotid vulnerable plaques. The area under the curve (AUC) of receiver operating characteristic (ROC) was used to evaluate the ability of FRS in assessing carotid vulnerable plaques and determine the appropriate cut-off value. Results A total of 134 subjects were included in this study, with a mean age of 72.3±5.5 years old and 62 males (46.3%). 17 cases (12.7%) had carotid vulnerable plaques. The FRS in vulnerable plaques group was significantly higher than that in non-vulnerable plaques group [37.8% (27.4%-60.0%) vs 16.6% (8.9%-27.4%), P=0.002]. In determining carotid vulnerable plaques, the OR of FRS per an increase of 10% was 1.556 (95% CI 1.204-2.011, P=0.001). ROC curve analysis showed that the AUC of FRS in determining the carotid vulnerable plaques was 0.732, and the appropriate cut-off value of FRS was 20%, with the sensitivity of 76.5% and specificity of 59.8%. Conclusions FRS can be preliminarily used to screen carotid vulnerable plaques. An advanced imaging examination is needed to evaluate carotid vulnerable plaques for the asymptomatic elderly when FRS is higher than 20%.关键词
老年人/弗明汉危险评分/颈动脉/易损斑块/磁共振成像Key words
Elderly/Framingham risk score/Carotid artery/Vulnerable plaque/Magnetic resonance imaging引用本文复制引用
姚容,赵锡海,周丹..弗明汉危险评分在无症状老年人颈动脉易损斑块筛查中的价值研究[J].中国卒中杂志,2019,14(12):1214-1219,6.基金项目
国家自然科学基金面上项目(81771825)北京市科委重大专项(D171100003017003)科技部"十三五"国家重点研发计划(2017YFC1307904) （81771825）
