中国神经再生研究（英文版）2020，Vol.15Issue(10)：1773-1784,12.DOI:10.4103/1673-5374.280301
Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone
Giancarlo Poiana 1Roberta Gioia 1Serena Sineri 1Silvia Cardarelli 1Giuseppe Lupo 1Emanuele Cacci1
作者信息
- 1. Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Rome, Italy
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摘要
Abstract
In rodents, well characterized neurogenic niches of the adult brain, such as the subventricular zone of the lateral ventricles and the subgranular zone of the hippocampus, support the maintenance of neural/stem progenitor cells (NSPCs) and the production of new neurons throughout the lifespan. The adult neurogenic process is dependent on the intrinsic gene expression signatures of NSPCs that make them competent for self-renewal and neuronal differentiation. At the same time, it is receptive to regulation by various extra-cellular signals that allow the modulation of neuronal production and integration into brain circuitries by various physiological stimuli. A drawback of this plasticity is the sensitivity of adult neurogenesis to alter-ations of the niche environment that can occur due to aging, injury or disease. At the core of the molecular mechanisms regulating neurogenesis, several transcription factors have been identified that maintain NSPC identity and mediate NSPC response to extrinsic cues. Here, we focus on REST, Egr1 and Dbx2 and their roles in adult neurogenesis, especially in the subventricular zone. We review recent work from our and other laboratories implicating these transcription factors in the control of NSPC proliferation and differentiation and in the response of NSPCs to extrinsic influences from the niche. We also discuss how their altered regulation may affect the neurogenic process in the aged and in the diseased brain. Finally, we highlight key open questions that need to be addressed to foster our understanding of the transcriptional mechanisms controlling adult neurogenesis.关键词
adult neurogenesis/aging/extracellular signaling/gene regulation/neural stem/progenitor cells/transcription factorsKey words
adult neurogenesis/aging/extracellular signaling/gene regulation/neural stem/progenitor cells/transcription factors引用本文复制引用
Giancarlo Poiana,Roberta Gioia,Serena Sineri,Silvia Cardarelli,Giuseppe Lupo,Emanuele Cacci..Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone[J].中国神经再生研究（英文版）,2020,15(10):1773-1784,12.
