首页|期刊导航|中国神经再生研究（英文版）|Role of activin receptor-like kinase 1in vascular development and cerebrovascular diseases
中国神经再生研究（英文版）2020，Vol.15Issue(10)：1807-1814,8.DOI:10.4103/1673-5374.280305
Role of activin receptor-like kinase 1in vascular development and cerebrovascular diseases
摘要
Abstract
Activin receptor-like kinase 1 (ALK1) is a transmembrane serine/threonine receptor kinase of the trans-forming growth factor beta (TGFβ) receptor superfamily. ALK1 is specifically expressed in vascular endothelial cells, and its dynamic changes are closely related to the proliferation of endothelial cells, the recruitment of pericytes to blood vessels, and functional differentiation during embryonic vascular de-velopment. The pathophysiology of many cerebrovascular diseases is today understood as a disorder of endothelial cell function and an imbalance in the proportion of vascular cells. Indeed, mutations in ALK1 and its co-receptor endoglin are major genetic risk factors for vascular arteriovenous malformation. Many studies have shown that ALK1 is closely related to the development of cerebral aneurysms, arteriovenous malformations, and cerebral atherosclerosis. In this review, we describe the various roles of ALK1 in the regulation of angiogenesis and in the maintenance of cerebral vascular homeostasis, and we discuss its relationship to functional dysregulation in cerebrovascular diseases. This review should provide new per-spectives for basic research on cerebrovascular diseases and offer more effective targets and strategies for clinical diagnosis, treatment, and prevention.关键词
activin receptor-like kinase 1/aneurysm/atherosclerotic plaque/endoglin/extracellular matrix protein/intracranial arteriovenous malformation/matrix metalloproteinase/pericyte/transforming growth factor beta 1 pathway/vascular developmentKey words
activin receptor-like kinase 1/aneurysm/atherosclerotic plaque/endoglin/extracellular matrix protein/intracranial arteriovenous malformation/matrix metalloproteinase/pericyte/transforming growth factor beta 1 pathway/vascular development引用本文复制引用
Jun-Mou Hong,Yi-Da Hu,Xiao-Qing Chai,Chao-Liang Tang..Role of activin receptor-like kinase 1in vascular development and cerebrovascular diseases[J].中国神经再生研究（英文版）,2020,15(10):1807-1814,8.基金项目
This work was supported by the National Natural Science Foundation of China, No. 81801175 (to CLT) （to CLT）
the Fundamental Research Funds for the Central Universities of China, No. WK9110000044 (to CLT) （to CLT）
China Scholarship Council, No. 201706270155 (to CLT) （to CLT）
the China Postdoctoral Science Foundation, No. 2019M662179 (to CLT) （to CLT）
and the Anhui Province Postdoctoral Science Foundation of China, No. 2019B324 (to CLT). （to CLT）
