国际医药卫生导报2020，Vol.26Issue(3)：370-373,4.DOI:10.3760/cma.j.issn.1007-1245.2020.03.024
食管癌组织PD-1及PD-L1表达对中晚期食管癌患者化疗近期疗效的影响
The effect of the expression of PD-1 and PD-L1 on the short-term effect of chemotherapy in patients with advanced esophageal cancer
摘要
Abstract
Objective To analyze the effect of the expression of programmed cell death protein-1 (PD-1) and PD-L1 of esophageal cancer tissue on the short-term effect of chemotherapy in patients with advanced esophageal cancer,so as to provide a reference for the treatment of advanced esophageal cancer.Methods 86 patients with advanced esophageal cancer in our hospital from January 2014 to January 2016 were collected.All patients were treated with gemcitabine and cisplatin.Before chemotherapy,the expression of PD-1 and PD-L1 of esophageal cancer tissue were detected by immunohistochemistry.The sensitivity of PD-1 and PD-L1 positive patients to chemotherapy were compared with that of PD-1 and PD-L1 negative patients at 3 months after chemotherapy.Results Among 86 cases of esophageal cancer,there were 44 cases of positive PD-1 and 43 cases of positive PD-L1,the positive rates were respectively 51.2％ and 50.0％.The sensitivity of PD-1 positive patients was 9.1％,which was significantly lower than 26.2％ of PD-1 negative patients (P＜0.05),and the sensitivity of PDL1 positive patients was 2.3％,which was significantly lower than 32.6％ of PD-L1 negative patients (P＜0.05).Conclusion The sensitivity of PD-1/PD-L1 positive patients to chemotherapy is significantly lower than that of PD-1/PD-L1 negative patients,which suggests that blocking PD-1/PD-L1 pathway may be a more appropriate treatment method for PD-1/PD-L1 positive esophageal cancer patients.关键词
食管癌/程序性细胞死亡蛋白-1/化疗/免疫功能/淋巴细胞Key words
Esophageal cancer/Programmed cell death protein-1/Chemotherapy/Immune function/Lymphocyte引用本文复制引用
徐小玉,吴兵,韩海娥..食管癌组织PD-1及PD-L1表达对中晚期食管癌患者化疗近期疗效的影响[J].国际医药卫生导报,2020,26(3):370-373,4.
