疑难病杂志2020，Vol.19Issue(4)：381-384,4.DOI:10.3969/j.issn.1671-6450.2020.04.013
血清肿瘤标记物检测在系统性红斑狼疮诊断中的价值
The value of tumor marker detection in assisting diagnosis of systemic lupus erythematosus
摘要
Abstract
Objective To investigate the diagnostic value of tumor markers CEA, CA125，CA199 and CA153 in systemic lupus erythematosus (SLE). Methods From July 2016 to December 2018，89 patients with SLE admitted to the Kidney and rheumatology Department of the Tangdu hospital were analyzed as SLE group. Then, according to SLEDAI, they were divided into 57 active SLE patients and 32 remission SLE patients. 100 cases of health examination were included in the control group. Erythrocyte sedimentation rate (ESR)，C-reactive protein(CRP)，serum CEA, CA125，CA199，CA153，immunological indexes (C3，C4，IgG, IgM，IGA) and anti dsDNA antibody were detected, Pearson method was used to analyze the correlation between tumor markers and SLEDAI score in patients with SLE，and to explore the clinical significance of serum tumor markers in the diagnosis and activity judgment of SLE. Results Compared with the healthy control group, the levels of ESR, CRP, IgG, IgA, IgM，serum CA199 and CA125 in SLE group were significantly higher, the levels of C3 and C4 were significantly lower, the difference was statistically significant(P<0. 01)，but the levels of CEA and CA153 in serum were not statistically significant(P>0. 05). Compared with the patients in the remission phase of SLE，the levels of C3 and C4 in the active phase of SLE decreased significantly, while the levels of IgG, IgA, IgM，CA125 and CA199 increased significantly (P<0. 01)，while the levels of CEA and CA153 had no significant difference (P>0.05).According to Pearson test, CA125，CA199 and anti dsDNA antibody were positively correlated with SLEDAI score(r=0. 479，0. 587，0. 664，P<0.01)，but not with CEA and CA153. Conclusion The levels of CA125，CA199 in serum of patients with SLE are increased, which is related to the activity of the disease.关键词
系统性红斑狼疮/肿瘤标记物/疾病活动度Key words
Systemic/lupus erythematosus/Tumor markers/Disease activity引用本文复制引用
龙洁,周璐,魏萌..血清肿瘤标记物检测在系统性红斑狼疮诊断中的价值[J].疑难病杂志,2020,19(4):381-384,4.基金项目
四川省科技厅重点研发项目(2018SZ0187) （2018SZ0187）
