中国医学创新2020，Vol.17Issue(7)：1-5,5.DOI:10.3969/j.issn.1674-4985.2020.07.001
不同雾化吸入方案对稳定期COPD患者血清NLRP3水平改变的临床研究
Clinical Study of Different Aerosol Inhalation Regimens on Serum NLRP3 Levels in Patients with Stable COPD
摘要
Abstract
objective: To analyze the effect of different atomization inhalation method on stable chronic obstructive pulmonary disease (COPD) and the effect on serum NLRP3 level Method: A retrospective analysis was performed on the clinical data of 50 patient with stable COPD who visited our outpatient clinic from May to October 2018 Depending on the treatment，they were divided into LAMA+LABA group and ICS+LABA group, 25 cases in each group. A total of 40 healthy patients admitted to hospital during the same period were selected as the control group The LAMA+LABA group was treated with Grononium Bromide/Formoterol Fumarate, the ICS+LABA group received Budesonide Formoterol inhalation Biochemical indexes and pulmonary function indexes of the two groups of patients were detected before and after treatment，and were compared and analyzed. Result: Before and after treatment，NLRP3 and IL-1 in LAMA+LABA group and ICS+LABA group were higher than those in control group，FEV1%and PEF% were lower than those of control group，the difference were statistically significant (P<0.05). Compared the level of NLRP3，IL-l，FEV1%，PEF% in LAMA+LABA group and ICS+LABA group，the difference were not statistically significant (P>0.05). Compared the levels of CRP，PCT and WBC in each group，the differences were not statistically significant (P>0.05).After treatment，NLRP3 and IL-1 in LAMA+LABA and ICS+LABA were lower than those before treatment，the differences were statistically signifioant (P<0.05).NLRP3 was positively correlated with IL-lβ(P<0.05)，while FEV1% and PEF% were negatively correlated (P<0.05).Conclusion: patients with COPD were treated with Grononium Bromide/Formoterol Fumarate and Budesonide Formoterol inhalation atomization inhalation with more significant therapeutic effect, which can clinically evaluate the prognosis of the disease according to NLRP3 level and guide clinical treatment.关键词
Nod样受体蛋白-3/慢性阻塞性肺疾病/雾化吸入/肺功能Key words
Nod-like receptor protein-3/Chronic obstructive pulmonary disease/Aerosol inhalation/Pulmonary function引用本文复制引用
黄志贞①,许惠卿①,赵洁敏①,刘凌云①,黄超文①..不同雾化吸入方案对稳定期COPD患者血清NLRP3水平改变的临床研究[J].中国医学创新,2020,17(7):1-5,5.基金项目
国家自然科学基金青年基金(81700031) （81700031）
江门市科技局立项(2018A083) （2018A083）
