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Potential synergic mechanism of Wutou-Gancao herb-pair by inhibiting efflux transporter P-glycoprotein

Yufei He Zihong Wei Ying Xie Xiulin Yi Yong Zeng Yazhuo Li Changxiao Liu

药物分析学报（英文）2020，Vol.10Issue(2)：178-186,9.

Potential synergic mechanism of Wutou-Gancao herb-pair by inhibiting efflux transporter P-glycoprotein

Yufei He ¹Zihong Wei ²Ying Xie ³Xiulin Yi ⁴Yong Zeng ²Yazhuo Li ³Changxiao Liu²

作者信息

1. Shenyang Pharmaceutical University,China
2. State Key Laboratory of Drug Delivery Technologies and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research,China
3. Tianjin Institute of Pharmaceutical Research New Drug Assessment Co. Ltd,China
4. State Key Laboratory of Quality Research in Chinese Medicine,Macau University of Science and Technology,Macau SAR,China
折叠

摘要

关键词

Wutou-Gancao herb-pair/P-glycoprotein/Caco-2 cells/Molecular docking/Pharmacokinetics/Anti-inflammatory effect

Key words

Wutou-Gancao herb-pair/P-glycoprotein/Caco-2 cells/Molecular docking/Pharmacokinetics/Anti-inflammatory effect

引用本文复制引用

Yufei He,Zihong Wei,Ying Xie,Xiulin Yi,Yong Zeng,Yazhuo Li,Changxiao Liu..Potential synergic mechanism of Wutou-Gancao herb-pair by inhibiting efflux transporter P-glycoprotein[J].药物分析学报（英文）,2020,10(2):178-186,9.

基金项目

This work was supported by National Key Research and Devel-opment Program (Grant 2016YFE0121400), National Natural Sci-ence Foundation of China (Grant No. 81430096), Macau Science and Technology Development Fund (006/2015/AMJ to Y.Xie), the pro-gram of Changjiang Scholars and innovative Research Team in University (No.IRT_14R41), and Tianjin Natural and Science Foundation (No. 17YFZCSY01170). The authors are also very grateful for Mr. Chuan LI and Dr. Haizhi ZHANG for their technical assistance and helpful discussion. （Grant 2016YFE0121400）

药物分析学报（英文）

OASCI

ISSN：2095-1779

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