广西医科大学学报2020，Vol.37Issue(3)：439-444,6.DOI:10.16190/j.cnki.45-1211/r.2020.03.017
维生素D和心房颤动因果关系的孟德尔随机化研究
Assessing the causal effect of vitamin D levels on the risk of atrial fibrillation: a Mendelian randomization study
摘要
Abstract
Objective: This study aimed to determine whether vitamin D levels are causally associated with atrial fibrillation (AF) risk by using Mendelian randomization (MR) analysis.Methods: Single-nucleotide polymorphisms associated with vitamin D concentrations were used as instrumental variables.The outcome summary-level data for AF were obtained from the largest meta-analysis of genome-wide association studies consisting of 65,446 AF cases and 522,744 controls.Inverse-variance weighted (IVW) method was used as the primary analysis to estimate the causal effect.Robustness of the results was tested via sensitivity analyses by using multiple methods.Results:Genetically high 25-hydroxyvitamin D concentration was not associated with AF risk based on the results of the IVW analysis,with an odd ratio of 1.05 (95％ confidence interval 0.84-1.31,P=0.667).Likewise,the results of the sensitivity analyses were consistent and supported our findings.MR-Egger regression indicated that directional pleiotropy did not bias the results (intercept=0.015,P=0.092).Conclusions: The MR analysis results do not support a causal association between vitamin D concentrations and AF risk.It is suggested that vitamin D supplementation may not reduce the risk of AF.关键词
孟德尔随机化/维生素D/因果推断/心房颤动Key words
Mendelian randomization/vitamin D/causality/atrial fibrillation分类
医药卫生引用本文复制引用
温政,李明丽,莫曾南..维生素D和心房颤动因果关系的孟德尔随机化研究[J].广西医科大学学报,2020,37(3):439-444,6.基金项目
This study was funded by the National Natural Science Foundation of China (81770759),Major Project of Guangxi Innovation Driven (AA18118016),and National Key Research and Development Program of China (2017YFC0908000). （81770759）
