广西医科大学学报2020，Vol.37Issue(4)：710-721,12.DOI:10.16190/j.cnki.45-1211/r.2020.04.026
男性睾酮与骨质疏松因果关系的两样本孟德尔随机化研究
Causal effect of testosterone on osteoporosis in men: a two-sample Mendelian randomization
摘要
Abstract
Objective:To examine the association between serum testosterone and osteoporosis in male by using Mendelian randomization (MR),so as to find potential targets for treatment.Methods:A two-sample MR analysis which involved three MR methods of inverse variance weighting,MR-Egger regression,and weighted median,was performed to assess the impact of testosterone on the risk of osteoporosis.Reduction by Dutasteride of Prostate Cancer Events randomized controlled trial (n =3225) on testosterone was taken as the exposure dataset,and the Genetic Factors of Osteoporosis Consortium (n=32965) on the femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) was taken as the outcome dataset.Results:There were three sets of instrument variants:Innovative set 1,Innovative set 2,and Conservative set.When using the Conservative set,the inverse variance weighting method suggested that no causal association between genetically determined higher testosterone status and FN BMD (Beta=-0.07;95％ CI:-0.17-0.04) or LS BMD (Beta=-0.06;95％ CI:-0.18-0.07).MR-Egger regression demonstrated the null-pleiotropy results,and the Q statistic did not indicate heterogeneity.Consistent results were obtained by using three MR methods and the other two sets.Conclusion:This study shows that serum testosterone has no influence on osteoporosis in male,suggesting that changes in serum testosterone status may not decrease risk of osteoporosis in men.关键词
睾酮/骨质疏松/骨密度/孟德尔随机化Key words
testosterone/osteoporosis/bone mineral density/Mendelian randomization分类
医药卫生引用本文复制引用
黎远帆,徐剑锋,颜赟坤,罗茜倩,温政,陈泽凤,白玉兰,龙新阳,林睿,莫曾南..男性睾酮与骨质疏松因果关系的两样本孟德尔随机化研究[J].广西医科大学学报,2020,37(4):710-721,12.基金项目
This work is supported by the National Natural Science Foundation of China (81770759) and National Key Research and Development Program of China (2017YFC0908000). （81770759）
