广西医科大学学报2020，Vol.37Issue(5)：878-886,9.DOI:10.16190/j.cnki.45-1211/r.2020.05.018
TLR10和BIRC5基因多态性对甲状腺乳头状癌发病风险的影响
Impact of Toll-like receptor 10 and Baculoviral IAP repeat containing 5 gene polymorphisms on risk of papillary thyroid carcinoma
摘要
Abstract
Objective:To investigate the association between rs11096956 (TLR10) and rs9904341 (BIRC5) genes thatsusceptibleto the papillary thyroid carcinoma (PTC).Methods:Four single nucleotide polymorphism (SNP) genotypes (rs11466653,rs11096956,rs11096955 and rs9904341) were assessed by using the Agena MassARRAY platform,and statistical analyses were performed by using chi-square,genetic model analysis and haplotype analysis.Results:The allele "C" of rs11096956 (TLR10) and allele "G" of rs9904341 (BIRC5) were associated with an increased risk of PTC (rs11096956:OR=1.26,95％ CI=1.09-1.97,P=0.031;rs9904341:OR=1.26,95％ CI=1.17-2.04,P=0.019).In the genetic model,logistic regression analyses revealed that the rs11096956 polymorphism was conferred an increased risk of PTC in the codominant model,the dominant model,and the log-additive model.The rs9904341 polymorphism was associated with an increased risk of PTC in the codominant model and the dominant model.In addition,thehaplotype "Trs11466653Trs11096956Crs11096955" of TLR10 was found to be associated with an increased risk of PTC.Stratification analysis revealed that rs11096956 (TLR10) and rs9904341 (BIRC5) were able to significantly increase the risk of PTC in females (P＜0.05).Conclusion:Our findings suggest that variations in rs11096956 (TLR10) and rs9904341 (BIRC5) areassociated with increased risk of PTC,particularly in the female.关键词
甲状腺乳头状癌/TLR10/BIRC5/基因多态性/病例一对照研究Key words
Papillary thyroid carcinoma (PTC)/Toll-like receptor 10(TLR10)/Baculoviral IAP repeat containing 5 (BIRC5)/genetic polymorphism/case-control study分类
医药卫生引用本文复制引用
李新喜,张磊,依地热斯·艾山,田野..TLR10和BIRC5基因多态性对甲状腺乳头状癌发病风险的影响[J].广西医科大学学报,2020,37(5):878-886,9.基金项目
This work is supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region (2019D01C295).We are grateful to the patients and control subjects for their participation in this study.We also thanks the clinicians and hospital staff who obtained the blood samples and performed data collection for this study. （2019D01C295）
