中山大学学报（自然科学版）2020，Vol.59Issue(1)：133-143,11.DOI:10.13471/j.cnki.acta.snus.2020.01.016
红树林真菌Aspergillus sp.次级代谢产物及其生物活性
Secondary metabolites from mangrove fungus Aspergillus sp.and their biological activities
摘要
Abstract
Seventeen compounds (1-17) were isolated from the marine fungus Aspergillus sp.Their structures were determined by nuclear magnetic resonance (NMR) spectroscopy and mass spectrum (MS).Among them,compound 1 was first found as a naturally occurring compound and the known compounds 2-17 were confirmed via spectrum and literatures.The bioactivities of selected compounds were preliminarily evaluated.The compound 2 exhibited moderate inhibitory activities toward three cancer cells,RPMI8226,OCI-MYS,and MCF-7 cells,and compound 10 had significant protective effects on prolonging the survival life of C.elegans under heat stress.In addition,the compound 9 and 7 showed slight inhibition effects against Streptococcus pyogenes and meanwhile the compound 17 possessed slightly inhibitory activity on Streptococcus pneumoniae.关键词
海洋真菌/天然产物/细胞毒活性/神经保护活性/抗菌活性Key words
marine fungus/natural products/cytotoxicity/neuroprotective effects/antibacterial effects分类
化学化工引用本文复制引用
郑颖琳,佟奕辰,孙英英,庞冀燕..红树林真菌Aspergillus sp.次级代谢产物及其生物活性[J].中山大学学报（自然科学版）,2020,59(1):133-143,11.基金项目
This work was supported by the National Natural Science Foundation of China (21172271),the Natural Science Foundation of Guangdong Province,China (Grant No.S2011020001231 and 2017A030313064) and Major Scientific and Technological Special Project of Administration of Ocean and Fisheries of Guangdong Province (GDME-2018C013).国家自然科学基金(21172271) （21172271）
广东省自然科学基金重点项目(S2011020001231,2017A030313064) （S2011020001231,2017A030313064）
广东省海洋与渔业厅省级促进经济发展专项资金(海洋经济发展用途)(GDME-2018C013) （海洋经济发展用途）
