广西医科大学学报2020，Vol.37Issue(1)：1-17,17.DOI:10.16190/j.cnki.45-1211/r.2020.01.001
细胞内蛋白质降解:通过溶酶体和泛素—蛋白酶体系统探索人类疾病和药物靶向治疗的未来
Intracellular protein degradation:exploring the future of human disease and drug-targeted therapy through lysosomal and ubiquitin-proteasome systems
摘要
Abstract
There are two main protein degradation systems in eukaryotic cells: autophagy-lysosome system and ubiquitin-proteasome system(UPS),which are essential to maintain protein homeostasis. This article re-views the composition,function,interaction,functional relevance of the autophago-lysosomal system and UPS, as well as the association with tumors,the feasibility as drug targets plays an important role in the future devel-opment of tumor-targeting drugs,and also has important reference value for a comprehensive understanding of the functions and mechanisms of the autophago-lysosome system and UPS.分类
医药卫生引用本文复制引用
Aaron Ciechanover..细胞内蛋白质降解:通过溶酶体和泛素—蛋白酶体系统探索人类疾病和药物靶向治疗的未来[J].广西医科大学学报,2020,37(1):1-17,17.
