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A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

Tobias Schwerd Steven A.Wall Jonathan Jung Timo Damm Claus-Christian Glüer Jürgen Scheller Stefan Rose-John E.Yvonne Jones Arian Laurence Andrew O.M.Wilkie Dirk Schmidt-Arras Freia Krause Holm H.Uhlig Stephen R.F.Twigg Dominik Aschenbrenner Yin-Huai Chen Uwe Borgmeyer Miryam Müller Santiago Manrique Neele Schumacher

骨研究（英文版）2020，Vol.8Issue(2)：157-168,12.
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骨研究（英文版）2020，Vol.8Issue(2)：157-168,12.

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

Tobias Schwerd 1Steven A.Wall 2Jonathan Jung 3Timo Damm 1Claus-Christian Glüer 4Jürgen Scheller 5Stefan Rose-John 5E.Yvonne Jones 6Arian Laurence 7Andrew O.M.Wilkie 8Dirk Schmidt-Arras 1Freia Krause 9Holm H.Uhlig 3Stephen R.F.Twigg 7Dominik Aschenbrenner 7Yin-Huai Chen 1Uwe Borgmeyer 10Miryam Müller 11Santiago Manrique 9Neele Schumacher1

作者信息

  • 1. Translational Gastroenterology Unit,John Radcliffe Hospital,University of Oxford,Oxford,UK
  • 2. Department of Pediatrics,Dr von Hauner Children's Hospital,LMU Munich,Munich,Germany
  • 3. Craniofacial Unit,Department of Plastic and Reconstructive Surgery,Oxford University Hospitals NHS Foundation Trust,John Radcliffe Hospital,Oxford,UK
  • 4. School of Medicine,University of Glasgow,Glasgow,UK
  • 5. Section Biomedical Imaging,Department of Radiology and Neuroradiology,University Medical Center Schleswig-Holstein,Kiel,Germany
  • 6. Institute of Biochemistry and Molecular Biology Ⅱ,Medical Faculty,Heinrich-Heine-University,Düsseldorf,Germany
  • 7. Christian-Albrechts-University Kiel,Institute of Biochemistry,Kiel,Germany
  • 8. Division of Structural Biology,Wellcome Trust Centre for Human Genetics,University of Oxford,Oxford,UK
  • 9. Clinical Genetics Group,MRC Weatherall Institute of Molecular Medicine,University of Oxford,John Radcliffe Hospital,Oxford,UK
  • 10. Department of Paediatrics,University of Oxford,Oxford,UK
  • 11. NIHR Oxford Biomedical Research Centre,Oxford,UK
  • 折叠

摘要

引用本文复制引用

Tobias Schwerd,Steven A.Wall,Jonathan Jung,Timo Damm,Claus-Christian Glüer,Jürgen Scheller,Stefan Rose-John,E.Yvonne Jones,Arian Laurence,Andrew O.M.Wilkie,Dirk Schmidt-Arras,Freia Krause,Holm H.Uhlig,Stephen R.F.Twigg,Dominik Aschenbrenner,Yin-Huai Chen,Uwe Borgmeyer,Miryam Müller,Santiago Manrique,Neele Schumacher..A variant in IL6ST with a selective IL-11 signaling defect in human and mouse[J].骨研究（英文版）,2020,8(2):157-168,12.

基金项目

This work was supported by funding from the Medical Research Council (MRC) through the WIMM Strategic Alliance (G0902418 and MC_UU_12025) and to E.Y.J.(G9900061),the Department of Health,UK,Quality,Improvement,Development and Initiative Scheme (QIDIS) (AOMW),and the Wellcome Trust (Project Grant 093329 to AOMW and SRFT （MRC）

Investigator Award 102731 to AOMW （）

grant 090532/Z/09/Z supporting the Wellcome Trust Centre for Human Genetics).H.H.U.is supported by the Crohn’s & Colitis Foundation of America (CCFA),the Leona M.and Harry B.Helmsley Charitable Trust.This project was funded by the NIHR Oxford Biomedical Research Centre.T.S.was supported by the Deutsche Forschungsgemeinschaft (SCHW1730/1-1).F.K.,D.S.-A.,and S.R.-J.was supported by the Deutsche For-schungsgemeinschaft (DFG),Bonn (grant number SFB841 to F.K.,D.S.-A.,and S.R.-J. （CCFA）

SFB877 to S.R.-J.) and the Cluster of Excellence "Inflammation at Interfaces" to S.R.-J. （）

骨研究（英文版）

OACSCDSCI

2095-4700

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