医学争鸣2020，Vol.11Issue(4)：30-33,37,5.DOI:10.13276/j.issn.1674-8913.2020.04.007
血-周围神经屏障的缺损参与瘙痒的发生
Disruption of the blood-nerve barrier contributes to pruritus
摘要
Abstract
Itchy substances originating from blood cells and associated nerve signaling are necessary for the happening of pruritus.The blood-nerve barrier (BNB) is a structure existing between blood vessels and nerve endings.Disruption of the BNB,which occurs in many pathological conditions,results in nerve inflammation and pain.Previous studies have demonstrated that BNB disruption and pruritus often coexist in the same diseases,such as diabetic neuropathy and chronic kidney disease.And cold pack therapy relieves pruritus while warm water exacerbates pruritus;pinching the calf or sitting cross-legged could relieve pruritus on feet and exerting substantial pressure on the itch site could relieve itch induced by the mosquito.According to the above references and facts,we hypothesize that disruption of the BNB is a critical step in the development of pruritus,and itchy substances and itch-associated nerve signaling are the basis of pruritus.This hypothesis emphasizes that the broken BNB is the most critical reason for pruritus rather than itchy substances or itch-associated nerve signaling,which can be used to explain the mechanism of pruritus in several pathological conditions and may lead to the development of new treatment in the clinic.关键词
瘙痒/痒/血-周围神经屏障/糖尿病/慢性肾病/内皮细胞Key words
pruritus/itch/blood-nerve barrier/diabetes mellitus/chronic kidney disease/endothelial cells分类
医药卫生引用本文复制引用
刘岳鹏..血-周围神经屏障的缺损参与瘙痒的发生[J].医学争鸣,2020,11(4):30-33,37,5.
