实用肝脏病杂志2020，Vol.23Issue(5)：687-690,4.DOI:10.3969/j.issn.1672-5069.2020.05.021
富马酸替诺福韦二吡呋酯联合双重血浆分子吸附系统序贯血浆置换治疗慢加急性乙型肝炎肝衰竭患者疗效分析
Efficacy of tenofovir disoproxil fumarate and double plasma molecular absorb system plus plasma exchange in treatment of patients with HBV-induced acute-on-chronic liver failure
董静 1刘龙梅 1陈照林 1陈曦 2宋海燕 1吕荣德 1张骏飞 3刘波1
作者信息
- 1. 230031 合肥市 解放军联勤保障部队第901 医院感染病科
- 2. 合肥京东方医院消化肝病科
- 3. 安徽医科大学第一附属医院感染病科
- 折叠
摘要
Abstract
Objective The aim of this study was to evaluate the efficacy of tenofovir disoproxil fumarate (TDF) and double plasma molecular absorb system (DPMAS) plus plasma exchange (PE) in treatment of patients with HBV-induced acute-on-chronic liver failure (HBV-ACLF). Methods 50 patients with HBV-ACLF HBV-ACLF were enrolled in this study and were divided into observation(n=25) and control group (n=25)，receiving TDF, DPMAS and PE combination or TDF and DPMAS treatment. Serum interleukin-6 level was assayed by ELISA. Results At the end of 12 week treatment, serum bilirubin level in the observation gnoup was ( 24.0μmol/L, INR was (1.1±0.3)，both significantly lower than[(31.6±15. 9 )μmol/L and(1.3±0. 4)，respectively, P<0.05]，while serum albumin level was (34.8±6.1)g/L, significantly higher than[(30.9±5.2)g/L, P<0.05] in the control; serum IL-6 level was (52.7±25.2)ng/L, procalcitonin level was (0.4±0.1)ng/L, platelet-to-lymphocyte ratio was (120.6±24.4), and neutrophil-to-lymphocyte ratio was (1.9±0. 5), all significantly lower than [(67.2±30. 8)ng/L, (0.5±0.2 ) ng/L, (139.3±26.7) and (2.4±0.6), respectively, P<0.05] in the control; the survival rate was significantly higher than that in the control group (72.0% vs. 48.0%,P<0.05). Conclusion TDF combined with DPMAS and PE in treatment of patients with HBV-ACLF is efficacious, which might he related to the reduction of blood endotoxin and improve liver function recovery.关键词
肝衰竭/乙型肝炎/富马酸替诺福韦二吡呋酯/血浆置换/双重血浆分子吸附系统/疗效Key words
Acute-on-chronic liver failure/Hepatitis B/Tenofovir disoproxil fumarate/Plasma exchange/ Double plasma molecular absorb system/ Efficacy引用本文复制引用
董静,刘龙梅,陈照林,陈曦,宋海燕,吕荣德,张骏飞,刘波..富马酸替诺福韦二吡呋酯联合双重血浆分子吸附系统序贯血浆置换治疗慢加急性乙型肝炎肝衰竭患者疗效分析[J].实用肝脏病杂志,2020,23(5):687-690,4.
