Certain research described in this paper was performed at the BioMedical Imaging and Therapy (BMIT) facility at the Canadian Light Source,which is supported by the Canada Foundation for Innovation,Natural Sciences and Engineering Research Council of Canada,the University of Saskatchewan,the Government of Saskatchewan,Western Economic Diversification Canada,the National Research Council Canada,and the Canadian Institutes of Health Research.We are grateful to the BMIT beamline user support staff,Drs George Belev,Adam Webb,Ning Zhu,Denise Miller,and Tomasz Wysokinski.The authors would further like to acknowledge the Children's Justice Act Program-Texas Center for the Judiciary who provided funding for research reported in this review. （BMIT）