广西医科大学学报2020，Vol.37Issue(8)：1512-1519,8.DOI:10.16190/j.cnki.45-1211/r.2020.08.019
同型半胱氨酸与估计肾小球滤过率和慢性肾病的因果关系研究
A study on the causal relationship of homocysteine to estimated glomerular filtration rate and chronic kidney disease
摘要
Abstract
Background: Traditional epidemiological studies have shown that homocysteine is related to estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD),but it is not clear whether there is causal relationship of homocysteine to eGFR or CKD.Therefore,the purpose of this study is to explore the causal relationship of homocysteine to eGFR and CKD.Methods:Using 18 single nucleotide polymorphisms (SNPs) significantly associated with homocysteine as instrumental variables,this study performed two-sample Mendelian randomization (MR) analyses and sensitivity analyses using summary data from genome-wide association study (n=567,460 for eGFR and CKD).Results: The results of inverse variance weighted,MR-Egger regression and weighted median analyses all showed that there was no causal effects of homocysteine on eGFR and CKD (All P＞ 0.05).Cochrane's Q test suggested the possibility of heterogeneity among the 11 SNPs significantly correlated with homocysteine.The MR-Egger regression showed that there was no directional pleiotropy.The leave-one-out analysis showed that the MR analysis results were not driven by a single SNP.Conclusion: There is no causal relationship of homocysteine to eGFR or CKD,that is,homocysteine does not directly cause eGFR reduction or CKD.Therefore,it is unlikely for homocysteine levels to be a predictive risk marker or clinically important target for eGFR reduction and/or CKD in the future.关键词
同型半胱氨酸/估计肾小球滤过率/慢性肾病/孟德尔随机化Key words
homocysteine/estimated glomerular filtration rate/chronic kidney disease/mendelian randomization分类
医药卫生引用本文复制引用
白玉兰,黄胜珠,陈泽凤,龙新阳,梁爽,林家莉,莫曾南,徐剑锋..同型半胱氨酸与估计肾小球滤过率和慢性肾病的因果关系研究[J].广西医科大学学报,2020,37(8):1512-1519,8.基金项目
This study was funded by the National Natural Science Foundation of China (81770759),National Key Research and Development Program of China (2017YFC0908000) （81770759）
