TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemiaOACSCDCSTPCD

作者：Yan-Ru Zhang;Shu-Hua Yi;Zhen Yu;Wen-Jie Xiong;Xu-Xiang Liu;Hui-Min Liu;Rui Cui;Qi Wang;Wen-Ming Chen;Lu-Gui Qiu

作者单位：State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, ChinaDepartment of Hematology, Beijing Chao Yang Hospital Affiliated to Capital Medical University, Beijing 100043, ChinaState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, ChinaState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, ChinaState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, ChinaDepartment of Pathology, City of Hope National Medical Center, Duarte 91010, CA, USAState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, ChinaState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, ChinaDepartment of Hematology, Tianjin First Center Hospital, Tianjin 300192, ChinaState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China

中文关键词：Chronic lymphocytic leukemiaTOSOB-cell receptor signaling pathwaySYKApoptosis

英文关键词：Chronic lymphocytic leukemiaTOSOB-cell receptor signaling pathwaySYKApoptosis

刊名：《中华医学杂志（英文版）》 2020 (17)

页码/页数：2090-2097,8

基金：This work was supported by grants from the National Nature Science Foundation of China (Nos.81200395 and 81970187),Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences grants (No.2017-I2M-3-018),and Fundamental Application and Advanced and Technology Research Program of Tianjin (No.15JCYBJC25100).

DOI：10.1097/CM9.0000000000000999