首页|期刊导航|世界中医药杂志（英文版）|Systematic Review and Meta-analysis of Shenfu Injection on Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease
世界中医药杂志（英文版）2020，Vol.6Issue(3)：276-283,8.DOI:10.4103/wjtcm.wjtcm_30_20
Systematic Review and Meta-analysis of Shenfu Injection on Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Systematic Review and Meta?analysis of Shenfu Injection on Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease
摘要
Abstract
The objective of the study was to systematically evaluate the e?cacy and safety of Shenfu injection in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease?(AECOPD). A?total of 15 randomized controlled trials involving 1198?patients were included. The results of meta?analysis showed that compared with the control group, the experimental group can improve the total clinical effective rate in AECOPD patients?(relative risk?=?1.15, 95％ confidence interval?[CI]?[1.09, 1.21], P?<?0.000?01), improve the pulmonary function levels: forced expiratory volume in one second? (FEV1)? (standardized mean difference?=? 1.88, 95％ CI? [0.89, 2.88], P?=? 0.000? 2) and the FEV1/forced vital capacity? (FVC) ratio? (FEV1/FVC)? (mean difference? [MD] = 3.96, 95％ CI? [2.74, 5.19], P?<? 0.000? 01); improve the arterial blood oxygen partial pressure?(MD?=?6.03, 95％ CI?[4.58, 7.48], P?<?0.000?01), and reduce the arterial blood partial pressure of carbon dioxide?(MD = ?4.59, 95％ CI?[?6.91, ?2.26], P?=?0.000?01), and the white blood cell count in pulmonary infection may be improved (MD = ?1.16, 95％ CI?[?1.63, ?0.68], P?<?0.000?01). The study showed that the e?cacy of experimental group in the treatment of AECOPD is better than control group. Due to the limitation of the number and quality of included studies, this conclusion needs more high quality studies to confirm.关键词
Acute exacerbation of chronic obstructive pulmonary disease/meta‑analysis/Shenfu injection/systematic reviewKey words
Acute exacerbation of chronic obstructive pulmonary disease/meta‑analysis/Shenfu injection/systematic review引用本文复制引用
Jian‑Guo Lin,Jian Lyu,Meng‑Hua Sun,Xing Liao,Yan‑Ming Xie..Systematic Review and Meta-analysis of Shenfu Injection on Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J].世界中医药杂志（英文版）,2020,6(3):276-283,8.基金项目
This study was funded by the Special Fund for Basic Scientific Research Expenses of Public Welfare Research Institutes at the central level?(Z0597). （Z0597）
