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AAV8 transduction capacity is reduced by prior exposure to endosome-like pH conditions

Jeffrey A. Lowell Kar Men Mah John L. Bixby Vance P. Lemmon

中国神经再生研究（英文版）2021，Vol.16Issue(5)：851-855,5.

AAV8 transduction capacity is reduced by prior exposure to endosome-like pH conditions

Jeffrey A. Lowell ¹Kar Men Mah ¹John L. Bixby ¹Vance P. Lemmon²

作者信息

1. Miami Project to Cure Paralysis, University of Miami, Miami, FL, USA
2. Department of Neurological Surgery, University of Miami, Miami, FL, USA
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摘要

关键词

adeno-associated virus/autolytic/capsid/low pH/protease/proteolytic/temperature/trafficking/transduction/viral inactivation

Key words

adeno-associated virus/autolytic/capsid/low pH/protease/proteolytic/temperature/trafficking/transduction/viral inactivation

分类

医药卫生

引用本文复制引用

Jeffrey A. Lowell,Kar Men Mah,John L. Bixby,Vance P. Lemmon..AAV8 transduction capacity is reduced by prior exposure to endosome-like pH conditions[J].中国神经再生研究（英文版）,2021,16(5):851-855,5.

基金项目

This work was supported by grants to JLB and VPL from the National Institutes of Health(NS100531),the Craig H.Neilsen Foundation(598684),and the Miami Project to Cure Paralysis.VPL holds the Walter G.Ross Distinguished Chair in Developmental Neuroscience. （NS100531）

中国神经再生研究（英文版）

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ISSN：1673-5374

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