纳微快报（英文）2021，Vol.13Issue(2)：28-44,17.
MOFs-Based Nitric Oxide Therapy for Tendon Regeneration
MOFs?Based Nitric Oxide Therapy for Tendon Regeneration
摘要
Abstract
Tendon regeneration is still a great challenge due to its avascular structure and low self-renewal capability. The nitric oxide (NO) therapy emerges as a promising treatment for inducing the regen-eration of injured tendon by angiogenesis. Here, in this study, a system that NO-loaded metal–organic frameworks (MOFs) encapsulated in poly-caprolactone (PCL)/gelatin (Gel) aligned coaxial scaffolds (NMPGA) is designed and prepared for tendon repair. In this system, NO is able to be released in vitro at a slow and stable average speed of 1.67 nM h?1 as long as 15 d without a burst release stage in the initial 48 h. Further-more, NMPGA can not only improve the tubular formation capability of endothelial cells in vitro but also obviously increase the blood perfusion near the injured tendon in vivo, leading to accelerating the maturity of collagen and recovery of biomechanical strength of the regenerated tendon tissue. As a NO-loaded MOFs therapeutic system, NMPGA can promote tendon regeneration in a shorter healing period with better bio-mechanical properties in comparison with control group by angiogenesis.Therefore, this study not only provides a promising scaffold for tendon regeneration, but also paves a new way to develop a NO-based therapy for biomedical application in the future.关键词
Nitric oxide/Metal–organic frameworks/Tendon/Tissue regeneration/AngiogenesisKey words
Nitric oxide/Metal–organic frameworks/Tendon/Tissue regeneration/Angiogenesis引用本文复制引用
Jun Chen,Dandan Sheng,Ting Ying,Haojun Zhao,Jian Zhang,Yunxia Li,He Xu,Shiyi Chen..MOFs-Based Nitric Oxide Therapy for Tendon Regeneration[J].纳微快报（英文）,2021,13(2):28-44,17.基金项目
This work was supported by National Key R&D Program of China (2016YFC1100300), National Natu-ral Science Foundation of China (Nos. 81772339, 8181101445 and 81972129), The Key Clinical Medicine Center of Shang-hai (2017ZZ01006), Sanming Project of Medicine in Shenzhen (SZSM201612078), Shanghai Rising-Star Project (18QB1400500), the Natural Science Foundation of Shanghai (No. 19ZR1437800) and The Introduction Project of Clinical Medicine Expert Team for Suzhou (SZYJTD201714), Development Project of Shanghai Peak Disciplines-Integrative Medicine (20180101) and Shang-hai Committee of Science and Technology (19441901600 and 19441902000). （2016YFC1100300）
